Dual Effect of Neutrophils on pIgR/Secretory Component in Human Bronchial Epithelial Cells: Role of TGF-𝛽

Figure 1

Dual effect of neutrophils on SC secretion. Confluent monolayers of Calu-3 cells were incubated in triplicates for 48 hrs with increasing numbers of neutrophils, from 0.3 × 10⁶ to 15 × 10⁶ cells. (a) SC concentration and (b) elastase activity were measured in supernatants, as described in Methods. Data are means ± SEM (𝑛=6 independent experiments). ^#𝑃=.08, ^∗𝑃≤.05 and ^∗∗𝑃≤.01 as compared with control.

(a)

(b)