Dual Effect of Neutrophils on pIgR/Secretory Component in Human Bronchial Epithelial Cells: Role of TGF-𝛽

Figure 2

Effect of Secretory Leucoproteinase Inhibitor (SLPI) on pIgR/SC production. Confluent Calu-3 monolayers were cultured with increasing numbers of neutrophils (0.6 × 10⁶ to 10 × 10⁶ cells) in the presence (dashed line) or in the absence (full line) of SLPI. After 48 hrs, SC production was measured in supernatants (black lines) and in cell lysates (grey lines). Data are means ± SD of one experiment (out of 2) in triplicates. ^∗𝑃≤.05 as compared with control.