Insights into the Biology of IRES Elements through Riboproteomic Approaches
(a) Schematic representation of the picornavirus genome, using as example the foot-and-mouth disease viral RNA. (b) Schematic representation of the hepatitis C virus genome. The IRESs are depicted in blue, with indication of the domains referred to in the text. The position of the functional initiator AUGs, as well as the preferential binding sites of eIFs and ITAFs are indicated. Stable stem-loops located at the and end of the viral RNA are depicted in grey.
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