Therapeutic Strategies for SLE Involving Cytokines: Mechanism-Oriented Therapies Especially IFN-𝛾 Targeting Gene Therapy

Figure 5

Cytokine targeted therapy will be expected to clinical application, but more detailed examination of side effects (e.g., development of infections, cancer, allergic diseases, and autoimmunity) is required. Clinical application to lupus must be based on their safety profile, adverse effects, risks, and advantages. Likewise, in this analysis we offer specific recommendations, based on evidence, for the best, is Th1/TH2 balance shift in vivo by using IL-4 gene therapy.