Maternal-Zygotic Epistasis and the Evolution of Genetic Diseases

Figure 1

The evolution of genetic diseases in the absence of epistasis. The simulations track the evolution of each allele depending on its pattern of inheritance: 𝜅, additive effect at a maternal effect locus; 𝐷_M, dominance effect at a maternal effect locus; 𝜙, additive effect at a zygotic effect locus; 𝐷_O, dominance effect at a zygotic effect locus. Purifying selection is assumed to be −0.1 in all cases.

(a)

(b)

(c)