Table of Contents Author Guidelines Submit a Manuscript
Journal of Biomedicine and Biotechnology
Volume 2010, Article ID 479364, 18 pages
http://dx.doi.org/10.1155/2010/479364
Review Article

Molecular and Therapeutic Potential and Toxicity of Valproic Acid

Laboratoire de Biologie Moléculaire et Cellulaire du Cancer (LBMCC), “Fondation de Recherche Cancer et Sang”, Hôpital Kirchberg, Kirchberg 2540, Luxembourg

Received 7 January 2010; Revised 3 May 2010; Accepted 6 June 2010

Academic Editor: Ronald E. Baynes

Copyright © 2010 Sébastien Chateauvieux et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [225 citations]

The following is the list of published articles that have cited the current article.

  • Diana Balasubramanian, John F. Pearson, and Martin A. Kennedy. View at Publisher · View at Google Scholar
  • J. Dave Barry, and Brandon K. Wills, “Neurotoxic Emergencies,” Neurologic Clinics, vol. 29, no. 3, pp. 539–+, 2011. View at Publisher · View at Google Scholar
  • Yoshikane Yamauchi, Yotaro Izumi, Keisuke Asakura, Toshinori Fukutomi, Akihiko Serizawa, Kenji Kawai, Masatoshi Wakui, Makoto Suematsu, and Hiroaki Nomori, “Lovastatin and valproic acid additively attenuate cell invasion in ACC-MESO-1 cells,” Biochemical and Biophysical Research Communications, vol. 410, no. 2, pp. 328–332, 2011. View at Publisher · View at Google Scholar
  • M. Kammerer, M. Fabritius, C. Carvalho, R. Muelhaupt, T. J. Feuerstein, and R. Trittler, “Valproate release from polycaprolactone implants prepared by 3D-bioplotting,” Pharmazie, vol. 66, no. 7, pp. 511–516, 2011. View at Publisher · View at Google Scholar
  • Rainer Glauben, and Britta Siegmund, “Inhibition of Histone Deacetylases in Inflammatory Bowel Diseases,” Molecular Medicine, vol. 17, no. 5-6, pp. 426–433, 2011. View at Publisher · View at Google Scholar
  • Natalia Lampon, and J Carlos Tutor, “A preliminary investigation on the possible association between diminished copper availability and non-alcoholic fatty liver disease in epileptic patients treated with valproic acid.,” Upsala journal of medical sciences, vol. 116, no. 2, pp. 148–54, 2011. View at Publisher · View at Google Scholar
  • Sébastien Chateauvieux, Serge Eifes, Franck Morceau, Christina Grigorakaki, Michael Schnekenburger, Estelle Henry, Mario Dicato, and Marc Diederich, “Valproic acid perturbs hematopoietic homeostasis by inhibition of erythroid differentiation and activation of the myelo-monocytic pathway,” Biochemical Pharmacology, vol. 81, no. 4, pp. 498–509, 2011. View at Publisher · View at Google Scholar
  • Sabbir Khan, Tauseef Ahmad, Chintan Vishnubhai Parekh, Priyanka Pushkarbhai Trivedi, Sapana Kushwaha, and Gopabandhu Jena, “Investigation on sodium valproate induced germ cell damage, oxidative stress and genotoxicity in male Swiss mice,” Reproductive Toxicology, vol. 32, no. 4, pp. 385–394, 2011. View at Publisher · View at Google Scholar
  • Werner, and Covenas, “Classical neurotransmitters and neuropeptides involved in generalized epilepsy: A focus on antiepileptic drugs,” Current Medicinal Chemistry, vol. 18, no. 32, pp. 4933–4948, 2011. View at Publisher · View at Google Scholar
  • Cristina Florean, Michael Schnekenburger, Cindy Grandjenette, Mario Dicato, and Marc Diederich, “Epigenomics of leukemia: from mechanisms to therapeutic applications,” Epigenomics, vol. 3, no. 5, pp. 581–609, 2011. View at Publisher · View at Google Scholar
  • Katrien Van Beneden, Caroline Geers, Marina Pauwels, Inge Mannaerts, Dierik Verbeelen, Leo A. van Grunsven, and Christiane Van den Branden, “Valproic Acid Attenuates Proteinuria and Kidney Injury,” Journal of The American Society of Nephrology, vol. 22, no. 10, pp. 1863–1875, 2011. View at Publisher · View at Google Scholar
  • Abdel-Wahab, and Metwally, “Ginkgo biloba enhances the anticonvulsant and neuroprotective effects of sodium valproate against kainic acid-induced seizures in mice,” Journal of Pharmacology and Toxicology, vol. 6, no. 8, pp. 679–690, 2011. View at Publisher · View at Google Scholar
  • Simon G. Royce, William Dang, Katherine Ververis, Nishika de Sampayo, Assam El Osta, Mimi L.K. Tang, and Tom C. Karagiannis, “Protective effects of valproic acid against airway hyperresponsiveness and airway remodeling in a mouse model of allergic airways disease,” Epigenetics, vol. 6, no. 12, pp. 1463–1470, 2011. View at Publisher · View at Google Scholar
  • Ellen M. McDonagh, Catherine Wassenaar, Sean P. David, Rachel F. Tyndale, Russ B. Altman, Michelle Whirl-Carrillo, and Teri E. Klein, “PharmGKB summary,” Pharmacogenetics and Genomics, vol. 22, no. 9, pp. 695–708, 2012. View at Publisher · View at Google Scholar
  • Toru Yasuda, Yasuto Nakata, and Hideki Mochizuki, “α-Synuclein and Neuronal Cell Death,” Molecular Neurobiology, vol. 47, no. 2, pp. 466–483, 2012. View at Publisher · View at Google Scholar
  • Ashley R. Kochanek, Eugene Y. Fukudome, Yongqing Li, Eleanor J. Smith, Baoling Liu, George C. Velmahos, Marc deMoya, David King, and Hasan B. Alam, “Histone Deacetylase Inhibitor Treatment Attenuates MAP Kinase Pathway Activation and Pulmonary Inflammation Following Hemorrhagic Shock in a Rodent Model,” Journal of Surgical Research, vol. 176, no. 1, pp. 185–194, 2012. View at Publisher · View at Google Scholar
  • S. Subbarayan, S. Thomas, and M. George, “Novel use of granulocyte colony stimulating factor as an adjunct for treatment of schizoaffective disorder complicated by sodium valproate induced agranulocytosis,” Indian Journal of Psychiatry, vol. 54, no. 3, pp. 291, 2012. View at Publisher · View at Google Scholar
  • Dorota Haznar-Garbacz, Grzegorz Garbacz, Friederike Eisenächer, Sandra Klein, and Werner Weitschies, “A novel liquefied gas based oral controlled release drug delivery system for liquid drug formulations,” European Journal of Pharmaceutics and Biopharmaceutics, vol. 81, no. 2, pp. 334–338, 2012. View at Publisher · View at Google Scholar
  • Omer Kutlu, Ali Cansu, Ersagun Karaguzel, Seren Gulsen Gurgen, Ozgur Koc, Metin Gur, and Guner Kemal Ozgur, “Effect of valproic acid treatment on penile structure in prepubertal rats,” Epilepsy Research, vol. 99, no. 3, pp. 306–311, 2012. View at Publisher · View at Google Scholar
  • Junji Saruwatari, Mariko Deguchi, Yuki Yoshimori, Madoka Noai, Shiho Yoshida, Naoki Ogusu, Kentaro Oniki, Shuichi Yoshida, Norio Yasui-Furukori, Sunao Kaneko, Takateru Ishitsu, and Kazuko Nakagawa, “Superoxide dismutase 2 Val16Ala polymorphism is a risk factor for the valproic acid-related elevation of serum aminotransferases,” Epilepsy Research, vol. 99, no. 1-2, pp. 183–186, 2012. View at Publisher · View at Google Scholar
  • Natalia Lampon, and J. Carlos Tutor, “Apparent clearance of valproic acid in elderly epileptic patients: estimation of the confounding effect of albumin concentration,” Upsala Journal Of Medical Sciences, vol. 117, no. 1, pp. 41–46, 2012. View at Publisher · View at Google Scholar
  • Laura G. Franko-Tobin, L. Vienna Mackey, Wei Huang, Xiangwei Song, Baofeng Jin, Jing Luo, Lynsie M. Morris, Minqiu Liu, Joseph A. Fuselier, David H. Coy, Lizi Wu, and Lichun Sun, “Notch1-Mediated Tumor Suppression in Cervical Cancer with the Involvement of SST Signaling and Its Application in Enhanced SSTR-Targeted Therapeutics,” Oncologist, vol. 17, no. 2, pp. 220–232, 2012. View at Publisher · View at Google Scholar
  • Changsu Han, Dong Suk Shim, Soo-Jung Lee, Ashwin A. Patkar, Prakash S. Masand, and Chi-Un Pae, “Association of chronic divalproex sodium use and brain atrophy in Alzheimer's disease,” Expert Review Of Neurotherapeutics, vol. 12, no. 2, pp. 155–158, 2012. View at Publisher · View at Google Scholar
  • Pia Larsson, Erik Ulfhammer, Mia Magnusson, Niklas Bergh, Sebastian Lunke, Assam El-Osta, Robert L. Medcalf, Per-Arne Svensson, Lena Karlsson, and Sverker Jern, “Role of histone acetylation in the stimulatory effect of valproic acid on vascular endothelial tissue-type plasminogen activator expression,” PLoS ONE, vol. 7, no. 2, 2012. View at Publisher · View at Google Scholar
  • Doru Georg Margineanu, “Systems biology impact on antiepileptic drug discovery,” Epilepsy Research, vol. 98, no. 2-3, pp. 104–115, 2012. View at Publisher · View at Google Scholar
  • C. M. Poloschek, and H. Jaegle, “Pharmacological concepts to treat hereditary retinal degenerations,” Ophthalmologe, vol. 109, no. 2, pp. 112–120, 2012. View at Publisher · View at Google Scholar
  • S. Chaudhary, and S. Parvez, “An in vitro approach to assess the neurotoxicity of valproic acid-induced oxidative stress in cerebellum and cerebral cortex of young rats,” Neuroscience, vol. 225, pp. 258–268, 2012. View at Publisher · View at Google Scholar
  • Tatiana V. Lipina, Fahmida Nipa Haque, Alexander McGirr, Paul C. Boutros, Thorsten Berger, Tak W. Mak, John C. Roder, and Albert H. C. Wong, “Prophylactic Valproic Acid Treatment Prevents Schizophrenia-Related Behaviour in Disc1-L100P Mutant Mice,” Plos One, vol. 7, no. 12, 2012. View at Publisher · View at Google Scholar
  • Ilenia Maini, Gaetano Cantalupo, Emanuela Claudia Turco, Fernando De Paolis, Cinzia Magnani, Liborio Parrino, Mario Giovanni Terzano, and Francesco Pisani, “Clinical and Polygraphic Improvement of Breathing Abnormalities After Valproate in a Case of Pitt-Hopkins Syndrome,” Journal Of Child Neurology, vol. 27, no. 12, pp. 1585–1588, 2012. View at Publisher · View at Google Scholar
  • Larry Baum, Patrick Kwan, Junji Saruwatari, Kazuko Nakagawa, Batoul Sadat Haerian, Hui Jan Tan, Azman Ali Raymond, and Zahurin Mohamed, “SCN1A IVS5N+5 polymorphism and response to sodium valproate: A multicenter study,” Pharmacogenomics, vol. 13, no. 13, pp. 1477–1485, 2012. View at Publisher · View at Google Scholar
  • Marjorie Boissinot, Martyn Inman, Aiden Hempshall, Sally R. James, Jason H. Gill, Peter Selby, David T. Bowen, Ronald Grigg, and Peter N. Cockerill, “Induction of differentiation and apoptosis in leukaemic cell lines by the novel benzamide family histone deacetylase 2 and 3 inhibitor MI-192,” Leukemia Research, vol. 36, no. 10, pp. 1304–1310, 2012. View at Publisher · View at Google Scholar
  • Anais Mockel, Cathy Obringer, Theodorus B.M. Hakvoort, Mathias Seeliger, Wouter H. Lamers, Corinne Stoetzel, Hélène Dollfus, and Vincent Marion, “Pharmacological modulation of the retinal unfolded protein response in bardet-biedl syndrome reduces apoptosis and preserves light detection ability,” Journal of Biological Chemistry, vol. 287, no. 44, pp. 37483–37494, 2012. View at Publisher · View at Google Scholar
  • Nadka Boyadjieva, and Miroslava Varadinova, “Epigenetics of psychoactive drugs,” Journal of Pharmacy and Pharmacology, vol. 64, no. 10, pp. 1349–1358, 2012. View at Publisher · View at Google Scholar
  • Lucio Tremolizzo, Jacopo C. DiFrancesco, Virginia Rodriguez-Menendez, Chiara Riva, Elisa Conti, Gloria Galimberti, Claudio Ruffmann, and Carlo Ferrarese, “Valproate induces epigenetic modifications in lymphomonocytes from epileptic patients,” Progress in Neuro-Psychopharmacology and Biological Psychiatry, vol. 39, no. 1, pp. 47–51, 2012. View at Publisher · View at Google Scholar
  • Sabine Geisse, and Bernd Voedisch, “Transient expression technologies: Past, present, and future,” Methods in Molecular Biology, vol. 899, pp. 203–219, 2012. View at Publisher · View at Google Scholar
  • B. Sirmagul, O. Atli, and S. Ilgin, “The effect of combination therapy on the plasma concentrations of traditional antiepileptics: A retrospective study,” Human & Experimental Toxicology, vol. 31, no. 10, pp. 971–980, 2012. View at Publisher · View at Google Scholar
  • José Christian Machado Ximenes, Emilio Crisóstomo Lima Verde, Maria da Graça Naffah-Mazzacoratti, and Glauce Socorro de Barros Viana, “Valproic Acid, a Drug with Multiple Molecular Targets Related to Its Potential Neuroprotective Action,” Neuroscience & Medicine, vol. 03, no. 01, pp. 107–123, 2012. View at Publisher · View at Google Scholar
  • Maria I. Morte, Bruno P. Carreira, Maria J. Falcão, António F. Ambrósio, Patrício Soares-da-Silva, Inês M. Araújo, and Caetana M. Carvalho, “Evaluation of neurotoxic and neuroprotective pathways affected by antiepileptic drugs in cultured hippocampal neurons,” Toxicology in Vitro, 2013. View at Publisher · View at Google Scholar
  • H Stedt, H Samaranayake, J Pikkarainen, A M Määttä, L Alasaarela, K Airenne, and S Ylä-Herttuala, “Improved therapeutic effect on malignant glioma with adenoviral suicide gene therapy combined with temozolomide,” Gene Therapy, 2013. View at Publisher · View at Google Scholar
  • Yuko Onishi, Akinobu Okada, Hiroko Noyori, Ai Okamura, Naama Hen, Boris Yagen, Meir Bialer, and Michio Fujiwara, “Teratology Study of Amide Derivatives of Branched Aliphatic Carboxylic Acids with 4-Aminobenzensulfonamide in NMRI Mice,” Birth Defects Research Part B: Developmental and Reproductive Toxicology, 2013. View at Publisher · View at Google Scholar
  • Pasquale Striano, and Vincenzo Belcastro, “Treating myoclonic epilepsy in children: state-of-the-art,” Expert Opinion on Pharmacotherapy, vol. 14, no. 10, pp. 1355–1361, 2013. View at Publisher · View at Google Scholar
  • Batoul Sadat Haerian, Larry Baum, Patrick Kwan, Hui Jun Tan, Azman Ali Raymond, and Zahurin Mohamed, “SCN1A, SCN2A and SCN3A gene polymorphisms and responsiveness to antiepileptic drugs: a multicenter cohort study and meta-analysis,” Pharmacogenomics, vol. 14, no. 10, pp. 1153–1166, 2013. View at Publisher · View at Google Scholar
  • Hideo Nishigori, Keisuke Kagami, Ai Takahashi, Yu Tezuka, Atsushi Sanbe, and Hidekazu Nishigori, “Impaired social behavior in chicks exposed to sodium valproate during the last week of embryogenesis,” Psychopharmacology, vol. 227, no. 3, pp. 393–402, 2013. View at Publisher · View at Google Scholar
  • Sanne A.B. Hermsen, Tessa E. Pronk, Evert-Jan van den Brandhof, Leo T.M. van der Ven, and Aldert H. Piersma, “Transcriptomic analysis in the developing zebrafish embryo after compound exposure: individual gene expression and pathway regulation,” Toxicology and Applied Pharmacology, 2013. View at Publisher · View at Google Scholar
  • J. Dave Barry, and Brandon K. Wills, “Neurotoxic Emergencies,” Psychiatric Clinics of North America, vol. 36, no. 2, pp. 219–244, 2013. View at Publisher · View at Google Scholar
  • Mary D. Gonzales, “Hplc Determination Of Valproic Acid In Plasma By Conjugation To A Hydrazide,” Journal of Liquid Chromatography & Related Technologies, vol. 36, no. 16, pp. 2209–2219, 2013. View at Publisher · View at Google Scholar
  • Daria Witt, Silke Kaulfuß, Peter Burfeind, Sandra von Hardenberg, Lennart Opitz, Gabriela Salinas-Riester, Felix Bremmer, Stefan Schweyer, Paul Thelen, and Jürgen Neesen, “Valproic acid inhibits the proliferation of cancer cells by re-expressing cyclin D2,” Carcinogenesis, vol. 34, no. 5, pp. 1115–1124, 2013. View at Publisher · View at Google Scholar
  • Reka R Letso, Andras J Bauer, Mitchell R Lunn, Wan Seok Yang, and Brent R Stockwell, “Small molecule screen reveals regulation of survival motor neuron protein abundance by Ras proteins.,” ACS chemical biology, vol. 8, no. 5, pp. 914–22, 2013. View at Publisher · View at Google Scholar
  • Satoshi Suda, Ken-ichiro Katsura, Takuya Kanamaru, Moeko Saito, and Yasuo Katayama, “Valproic acid attenuates ischemia-reperfusion injury in the rat brain through inhibition of oxidative stress and inflammation,” European Journal of Pharmacology, vol. 707, no. 1-3, pp. 26–31, 2013. View at Publisher · View at Google Scholar
  • Hiromi I. Wettersten, and Robert H. Weiss, “Potential biofluid markers and treatment targets for renal cell carcinoma,” Nature Reviews Urology, 2013. View at Publisher · View at Google Scholar
  • Yogita Ghodke-Puranik, Caroline F. Thorn, Jatinder K. Lamba, J. Steven Leeder, Wen Song, Angela K. Birnbaum, and Russ B. Altman, “Valproic acid pathway: pharmacokinetics and pharmacodynamics,” Pharmacogenetics and Genomics, vol. 23, no. 4, pp. 236–241, 2013. View at Publisher · View at Google Scholar
  • Mark D. Parker, and Walter F. Boron, “The Divergence, Actions, Roles, And Relatives Of Sodium-Coupled Bicarbonate Transporters,” Physiological Reviews, vol. 93, no. 2, pp. 803–959, 2013. View at Publisher · View at Google Scholar
  • P. Maciejak, J. Szyndler, D. Turzyńska, A. Sobolewska, K. Kołosowska, M. Lehner, and A. Płaźnik, “The kynurenine pathway: A missing piece in the puzzle of valproate action?,” Neuroscience, vol. 234, pp. 135–145, 2013. View at Publisher · View at Google Scholar
  • A. Androutsellis-Theotokis, G. P. Chrousos, R. D. McKay, A. H. DeCherney, and T. Kino, “Expression Profiles of the Nuclear Receptors and Their Transcriptional Coregulators During Differentiation of Neural Stem Cells,” Hormone And Metabolic Research, vol. 45, no. 2, pp. 159–168, 2013. View at Publisher · View at Google Scholar
  • Daniel W. Nelson, Christopher R. Porta, Derek P. McVay, Shashikumar K. Salgar, and Matthew J. Martin, “Effects of histone deacetylase inhibition on 24-hour survival and end-organ injury in a porcine trauma model: A prospective, randomized trial,” Journal of Trauma and Acute Care Surgery, vol. 75, no. 6, pp. 1031–1039, 2013. View at Publisher · View at Google Scholar
  • Zheng Sun, Vignesh Selvakumaran, Kyoung-Jae Won, Mitchell A. Lazar, Dan Feng, Bin Fang, Shannon E. Mullican, Seo-Hee You, Hee-Woong Lim, Logan J. Everett, Christopher S. Nabel, and Yun Li, “Deacetylase-Independent function of HDAC3 in transcription and metabolism requires nuclear receptor corepressor,” Molecular Cell, vol. 52, no. 6, pp. 769–782, 2013. View at Publisher · View at Google Scholar
  • Elisa C.M. Tonk, Joshua F. Robinson, Aart Verhoef, Peter T. Theunissen, Jeroen L.A. Pennings, and Aldert H. Piersma, “Valproic acid-induced gene expression responses in rat whole embryo culture and comparison across in vitro developmental and non-developmental models,” Reproductive Toxicology, vol. 41, pp. 57–66, 2013. View at Publisher · View at Google Scholar
  • Riikka J. Lund, Maheswara Reddy Emani, Ivana Barbaric, Virpi Kivinen, Mark Jones, Duncan Baker, Paul Gokhale, Matti Nykter, Riitta Lahesmaa, and Peter W. Andrews, “Karyotypically abnormal human ESCs are sensitive to HDAC inhibitors and show altered regulation of genes linked to cancers and neurological diseases,” Stem Cell Research, vol. 11, no. 3, pp. 1022–1036, 2013. View at Publisher · View at Google Scholar
  • Katrin Hayess, Christian Riebeling, Ralph Pirow, Matthias Steinfath, Dana Sittner, Birgitta Slawik, Andreas Luch, and Andrea E.M. Seiler, “The DNT-EST: A predictive embryonic stem cell-based assay for developmental neurotoxicity testing in vitro,” Toxicology, 2013. View at Publisher · View at Google Scholar
  • Angélica Fajardo, Francisco Olmos, and Lina Sarmiento, “Ácido valproico y riesgo de sangrado perioperatorio. Reporte de caso y revisión de la literatura,” Revista Colombiana de Anestesiología, vol. 41, no. 1, pp. 61–64, 2013. View at Publisher · View at Google Scholar
  • Angélica Fajardo, Francisco Olmos, and Lina Sarmiento, “Valproic acid and the risk of perioperative bleeding. Case report and literature review,” Colombian Journal of Anesthesiology, vol. 41, no. 1, pp. 61–64, 2013. View at Publisher · View at Google Scholar
  • Kenichi Kuriyama, Motoyasu Honma, Takuya Yoshiike, and Yoshiharu Kim, “Valproic acid but not d-cycloserine facilitates sleep-dependent offline learning of extinction and habituation of conditioned fear in humans,” Neuropharmacology, vol. 64, pp. 424–431, 2013. View at Publisher · View at Google Scholar
  • Chi-Tso Chiu, Zhifei Wang, Joshua G. Hunsberger, and De-Maw Chuang, “Therapeutic Potential of Mood Stabilizers Lithium and Valproic Acid: Beyond Bipolar Disorder,” Pharmacological Reviews, vol. 65, no. 1, pp. 105–142, 2013. View at Publisher · View at Google Scholar
  • Khan, and Jena, “Effect of sodium valproate on the toxicity of cyclophosphamide in the testes of mice: Influence of pre-and post-treatment schedule,” Toxicology International, vol. 20, no. 1, pp. 68–76, 2013. View at Publisher · View at Google Scholar
  • Ewa Chodurek, Magdalena Zdybel, and Barbara Pilawa, “Application of EPR spectroscopy to examination of free radicals in melanins from A-375 and G-361 human melanoma malignum cells,” Journal of Applied Biomedicine, vol. 11, no. 3, pp. 173–185, 2013. View at Publisher · View at Google Scholar
  • Hai-Fei Chen, Li-Ping Xu, Zhi-Yong Luo, Zi-Qiang Yu, Zheng-Yang Li, Qing-Ya Cui, Long-Mei Qin, Yong-Ya Ren, Hong-Shi Shen, Jie-Qing Tang, Ling-Juan Jin, Jing-Jing Zhu, Jing Wang, Ke-Yuan Wang, Tian-Qin Wu, and Zhao-Yue Wang, “Valproic acid-associated low fibrinogen and delayed intracranial hemorrhage: case report and mini literature review,” Drug Design Development and Therapy, vol. 7, pp. 767–770, 2013. View at Publisher · View at Google Scholar
  • Katrien Van Beneden, Inge Mannaerts, Marina Pauwels, Christiane Van den Branden, and Leo A van Grunsven, “HDAC inhibitors in experimental liver and kidney fibrosis,” Fibrogenesis & Tissue Repair, vol. 6, no. 1, pp. 1, 2013. View at Publisher · View at Google Scholar
  • Rosanna Weksberg, Darci T. Butcher, Daria Grafodatskaya, Sanaa Choufani, and Benjamin Tycko, “Epigenetics,” Emery and Rimoin's Principles and Practice of Medical Genetics, pp. 1–31, 2013. View at Publisher · View at Google Scholar
  • Yuki Kondo, Takahiro Iwao, Sachimi Yoshihashi, Kayo Mimori, Ruri Ogihara, Kiyoshi Nagata, Kouichi Kurose, Masayoshi Saito, Takuro Niwa, Takayoshi Suzuki, Naoki Miyata, Shigeru Ohmori, Katsunori Nakamura, and Tamihide Matsunaga, “Histone Deacetylase Inhibitor Valproic Acid Promotes the Differentiation of Human Induced Pluripotent Stem Cells into Hepatocyte-Like Cells,” Plos One, vol. 9, no. 8, 2014. View at Publisher · View at Google Scholar
  • Mohamed-Salah I. Abaza, Abdul-Majeed Bahman, and Raja'a J. Al-Attiyah, “Valproic acid, an anti-epileptic drug and a histone deacetylase inhibitor, in combination with proteasome inhibitors exerts antiproliferative, pro-apoptotic and chemosensitizing effects in human colorectal cancer cells: Underlying molecular mechanisms,” International Journal of Molecular Medicine, vol. 34, no. 2, pp. 513–532, 2014. View at Publisher · View at Google Scholar
  • A. Amrani, O. Benaissa, N. Boubekri, D. Zama, K. Biod, N. Beroal, F. Benayache, S. Benayache, and S. Bettuzzi, “Effet hépatoprotecteur et antiradicalaire d’un extrait butanolique de Rhantherium suaveolens,” Phytothérapie, 2014. View at Publisher · View at Google Scholar
  • Denise Lego, Markus Plaumann, Thomas Trantzschel, Joachim Bargon, Henning Scheich, Gerd Buntkowsky, Torsten Gutmann, Grit Sauer, Johannes Bernarding, and Ute Bommerich, “Parahydrogen-induced polarization of carboxylic acids: a pilot study of valproic acid and related structures,” Nmr in Biomedicine, vol. 27, no. 7, pp. 810–816, 2014. View at Publisher · View at Google Scholar
  • Sourajit Soumyaranjan Das, Gargi Gouranga Nanda, and Debasmita Pankaj Alone, “ Artemisinin and Curcumin inhibit Drosophila brain tumor, prolong life span, and restore locomotor activity ,” IUBMB Life, 2014. View at Publisher · View at Google Scholar
  • Weixiang Guo, Keita Tsujimura, Maky Otsuka, Koichiro Irie, Katsuhide Igarashi, Kinichi Nakashima, and Xinyu Zhao, “VPA Alleviates Neurological Deficits and Restores Gene Expression in a Mouse Model of Rett Syndrome,” Plos One, vol. 9, no. 6, 2014. View at Publisher · View at Google Scholar
  • Mojtaba Abdul Roda, Mariam Sadik, Amit Gaggar, Matthew T. Hardison, Michael J. Jablonsky, Saskia Braber, James Edwin Blalock, Frank A. Redegeld, Gert Folkerts, and Patricia L. Jackson, “Targeting Prolyl Endopeptidase with Valproic Acid as a Potential Modulator of Neutrophilic Inflammation,” Plos One, vol. 9, no. 5, 2014. View at Publisher · View at Google Scholar
  • Deb Kumar Mojumder, and Radhames Ramos De Oleo, “Differential ammonia decay kinetics indicates more than one concurrent etiological mechanism for symptomatic hyperammonemia caused by valproate overdose,” Indian Journal of Pharmacology, vol. 46, no. 3, pp. 345–347, 2014. View at Publisher · View at Google Scholar
  • Piotr Maciejak, Janusz Szyndler, Karolina Kolosowska, Danuta Turzynska, Alicja Sobolewska, Jerzy Walkowiak, and Adam Plaznik, “Valproate Disturbs the Balance Between Branched and Aromatic Amino Acids in Rats,” Neurotoxicity Research, vol. 25, no. 4, pp. 358–368, 2014. View at Publisher · View at Google Scholar
  • Pavel Bezecny, “Histone deacetylase inhibitors in glioblastoma: pre-clinical and clinical experience,” Medical Oncology, vol. 31, no. 6, 2014. View at Publisher · View at Google Scholar
  • S. Schwertheim, K. Worm, K. W. Schmid, and S-Y. Sheu-Grabellus, “Valproic Acid Downregulates NF-kB p50 Activity and IRAK-1 in a Progressive Thyroid Carcinoma Cell Line,” Hormone and Metabolic Research, vol. 46, no. 03, pp. 181–186, 2014. View at Publisher · View at Google Scholar
  • Yu-Ting Tseng, Pei-Shen Ho, Cheng-Fa Wang, and Chih-Sung Liang, “Valproic Acid-Induced Thrombocytopenia May Cause Wound Non-Healing in Individuals with Schizophrenia,” Psychosomatics, 2014. View at Publisher · View at Google Scholar
  • Zhengcai Liu, Yongqing Li, Wei Chong, Danielle K. Deperalta, Xiuzhen Duan, Baoling Liu, Ihab Halaweish, Peter Zhou, and Hasan B. Alam, “Creating a Prosurvival Phenotype Through a Histone Deacetylase Inhibitor in a Lethal Two-Hit Model,” Shock, vol. 41, no. 2, pp. 104–108, 2014. View at Publisher · View at Google Scholar
  • Michael R. Cassidy, Alan C. Sherburne, Holly K. Sheldon, Melanie L. Gainsbury, Stanley Heydrick, and Arthur F. Stucchi, “Histone deacetylase inhibitors decrease intra-abdominal adhesions with one intraoperative dose by reducing peritoneal fibrin deposition pathways,” Surgery, vol. 155, no. 2, pp. 234–244, 2014. View at Publisher · View at Google Scholar
  • Judith Brunn, Viktor Wiroth, Michael Kowalski, Uwe Runge, and Michael Sabolek, “Valproic acid in normal therapeutic concentration has no neuroprotective or differentiation influencing effects on long term expanded murine neural stem cells,” Epilepsy Research, 2014. View at Publisher · View at Google Scholar
  • Tianci Chu, Hengxing Zhou, Lu Lu, Xiaohong Kong, Tianyi Wang, Bin Pan, and Shiqing Feng, “Valproic acid-mediated neuroprotection and neurogenesis after spinal cord injury: from mechanism to clinical potential,” Regenerative Medicine, pp. 1–16, 2014. View at Publisher · View at Google Scholar
  • Antonio Avallone, Maria Carmela Piccirillo, Paolo Delrio, Biagio Pecori, Elena Di Gennaro, Luigi Aloj, Fabiana Tatangelo, Valentina D'Angelo, Cinzia Granata, Ernesta Cavalcanti, Nicola Maurea, Piera Maiolino, Franco Bianco, Massimo Montano, Lucrezia Silvestro, Manuela Terranova Barberio, Maria Serena Roca, Massimo Di Maio, Pietro Marone, Gerardo Botti, Antonella Petrillo, Gennaro Daniele, Secondo Lastoria, Vincenzo R. Iaffaioli, Giovanni Romano, Corradina Caraco, Paolo Muto, Ciro Gallo, Francesco Perrone, and Alfredo Budillon, “Phase 1/2 study of valproic acid and short-course radiotherapy plus capecitabine as preoperative treatment in low-moderate risk rectal cancer-V-shoRT-,” Bmc Cancer, vol. 14, 2014. View at Publisher · View at Google Scholar
  • Sabbir Khan, and Gopabandhu Jena, “Sodium valproate, a histone deacetylase inhibitor ameliorates cyclophosphamide-induced genotoxicity and cytotoxicity in the colon of mice,” Journal of Basic and Clinical Physiology and Pharmacology, vol. 25, no. 4, pp. 329–339, 2014. View at Publisher · View at Google Scholar
  • Chun-Yi Wu, and Chi-Yu Lu, “Derivatization oriented strategy for enhanced detection of valproic acid and its metabolites in human plasma and detection of valproic acid induced reactive oxygen species associated protein modifications by mass spectrometry,” Journal of Chromatography A, 2014. View at Publisher · View at Google Scholar
  • Anne Trecul, Franck Morceau, Anthoula Gaigneaux, Michael Schnekenburger, Mario Dicato, and Marc Diederich, “Valproic acid regulates erythro-megakaryocytic differentiation through the modulation of transcription factors and microRNA regulatory micro-networks,” Biochemical Pharmacology, vol. 92, no. 2, pp. 299–311, 2014. View at Publisher · View at Google Scholar
  • Tianci Chu, Hengxing Zhou, Tianyi Wang, Lu Lu, Fuyuan Li, Bin Liu, Xiaohong Kong, and Shiqing Feng, “In vitro characteristics of Valproic acid and all-trans-retinoic acid and their combined use in promoting neuronal differentiation while suppressing astrocytic differentiation in neural stem cells,” Brain Research, 2014. View at Publisher · View at Google Scholar
  • Melody Furnari, Constance L. L. Saw, Ah-Ng T. Kong, and George C. Wagner, “Animal Model of Autistic Regression: Link to Toxicant-Induced Oxidative Stress,” Studies on Psychiatric Disorders, pp. 393–416, 2014. View at Publisher · View at Google Scholar
  • Rima Woods, and Janine M. Lasallepp. 321–342, 2014. View at Publisher · View at Google Scholar
  • Paul Jennings, Michael Schwarz, Brigitte Landesmann, Silvia Maggioni, Marina Goumenou, David Bower, Martin O. Leonard, and Jeffrey S. Wiseman, “SEURAT-1 liver gold reference compounds: a mechanism-based review,” Archives of Toxicology, 2014. View at Publisher · View at Google Scholar
  • Oday Alsarraf, Jie Fan, Mohammad Dahrouj, C. James Chou, Phillip W. Yates, and Craig E. Crosson, “Acetylation Preserves Retinal Ganglion Cell Structure and Function in a Chronic Model of Ocular Hypertension,” Investigative Ophthalmology & Visual Science, vol. 55, no. 11, pp. 7486–7493, 2014. View at Publisher · View at Google Scholar
  • Ryan A. Henry, Yin-Ming Kuo, Vikram Bhattacharjee, Timothy J. Yen, and Andrew J. Andrews, “Changing the Selectivity of p300 by Acetyl-CoA Modulation of Histone Acetylation,” ACS Chemical Biology, pp. 141106135622003, 2014. View at Publisher · View at Google Scholar
  • Rekha Dwivedi, Yogendra Kumar Gupta, Meenakshi Singh, Rupa Joshi, Prabhakar Tiwari, Thomas Kaleekal, and Manjari Tripathi, “Correlation of saliva and serum free valproic acid concentrations in persons with epilepsy,” Seizure, 2014. View at Publisher · View at Google Scholar
  • Melody A. Furnari, Constance Lay-Lay Saw, Ah-Ng Kong, and George C. Wagner, “Altered Behavioral Development in Nrf2 Knockout Mice Following Early Postnatal Exposure to Valproic Acid,” Brain Research Bulletin, 2014. View at Publisher · View at Google Scholar
  • Henry G. S. Martin, and Olivier J. Manzoni, “Late onset deficits in synaptic plasticity in the valproic acid rat model of autism,” Frontiers in Cellular Neuroscience, vol. 8, 2014. View at Publisher · View at Google Scholar
  • Elisa Conti, Guido Cavaletti, Carlo Ferrarese, Lucio Tremolizzo, Virginia Rodriguez-Menendez, and Chiara Paola Zoia, “Novel therapeutic targets in neuropsychiatric disorders: The neuroepigenome,” Current Pharmaceutical Design, vol. 20, no. 11, pp. 1831–1839, 2014. View at Publisher · View at Google Scholar
  • S. Chateauvieux, F. Morceau, and M. Diederich, “Valproic Acid,” Encyclopedia of Toxicology, pp. 905–908, 2014. View at Publisher · View at Google Scholar
  • Vahid Haghpanah, Mohsen Malehmir, Bagher Larijani, Shahin Ahmadian, Kamran Alimoghaddam, Ramin Heshmat, Ardeshir Ghavamzadeh, Khadijeh Adabi, and Seyed H. Ghaffari, “The Beneficial Effects of Valproic Acid in Thyroid Cancer Are Mediated through Promoting Redifferentiation and Reducing Stemness Level: An In Vitro Study,” Journal of Thyroid Research, vol. 2014, pp. 1–9, 2014. View at Publisher · View at Google Scholar
  • Chih-Zen Chang, Chih-Lung Lin, Shu-Chuan Wu, and Aij-Lie Kwan, “Purpurogallin, a Natural Phenol, Attenuates High-Mobility Group Box 1 in Subarachnoid Hemorrhage Induced Vasospasm in a Rat Model,” International Journal of Vascular Medicine, vol. 2014, pp. 1–9, 2014. View at Publisher · View at Google Scholar
  • Marite Punapart, Mall Eltermaa, Julia Oflijan, Silva Sütt, Anne Must, Sulev Kõks, Leonard C. Schalkwyk, Catherine Fernandes, Eero Vasar, Ursel Soomets, and Anton Terasmaa, “Effect of Chronic Valproic Acid Treatment on Hepatic Gene Expression Profile in Wfs1 Knockout Mouse,” PPAR Research, vol. 2014, pp. 1–11, 2014. View at Publisher · View at Google Scholar
  • Yu-Ting Tai, Wen-Yuan Lee, Fei-Peng Lee, Tien-Jen Lin, Chia-Lin Shih, Jia-Yi Wang, Wen-Ta Chiu, and Kuo-Sheng Hung, “Low Dose of Valproate Improves Motor Function after Traumatic Brain Injury,” BioMed Research International, vol. 2014, pp. 1–8, 2014. View at Publisher · View at Google Scholar
  • Diana Markozashvili, Vincent Ribrag, and Yegor S. Vassetzky, “Histone deacetylase inhibitors and epigenetic regulation in lymphoid malignancies,” Investigational New Drugs, 2015. View at Publisher · View at Google Scholar
  • Ihab Halaweish, Hasan B. Alam, Vahagn Nikolian, Patrick Georgoff, and Yongqing Li, “Creating a "Prosurvival phenotype" through histone deacetylase inhibition: Past, present, and future,” Shock, vol. 44, pp. 6–16, 2015. View at Publisher · View at Google Scholar
  • Aleksei Rakitin, Sulev Kõks, Ene Reimann, Ele Prans, and Sulev Haldre, “Changes in the Peripheral Blood Gene Expression Profile Induced by 3 Months of Valproate Treatment in Patients with Newly Diagnosed Epilepsy,” Frontiers in Neurology, vol. 6, 2015. View at Publisher · View at Google Scholar
  • Seyyedeh Nazanin Amiryaghoubi, and Mirzaagha Babazadeh, “Novel Polymeric Prodrugs of Valproic Acid as Anti-Epilepsy Drugs: Synthesis, Characterization and In-vitro Evaluation,” Tropical Journal Of Pharmaceutical Research, vol. 14, no. 7, pp. 1183–1189, 2015. View at Publisher · View at Google Scholar
  • Katalin Tóth, Tamás Bűdi, Ádám Kiss, Manna Temesvári, Edit Háfra, Andrea Nagy, Zsuzsa Szever, and Katalin Monostory, “ Phenoconversion of CYP2C9 in epilepsy limits the predictive value of CYP2C9 genotype in optimizing valproate therapy ,” Personalized Medicine, vol. 12, no. 3, pp. 199–207, 2015. View at Publisher · View at Google Scholar
  • Gabor P. Molnar, Kyle J. Stephens, Lauren V. George, and Jonathan T. Stewart, “A critical interaction between ertapenem and valproic acid,” Journal of Clinical Psychopharmacology, vol. 35, no. 3, pp. 348–350, 2015. View at Publisher · View at Google Scholar
  • Ruhui Song, Dohyeon Yu, Jiseon Yoon, and Jinho Park, “Valproic acid attenuates the expression of pro-inflammatory cytokines lipopolysaccharide-treated canine peripheral blood mononuclear cells (in vitro) and in a canine endotoxemia model (in vivo),” Veterinary Immunology and Immunopathology, 2015. View at Publisher · View at Google Scholar
  • Abidemi J. Akindele, Edafe Otuguor, Dhirendra Singh, Duncan Ota, and Adokiye S. Benebo, “Hypoglycemic, antilipidemic and antioxidant effects of valproic acid in alloxan-induced diabetic rats,” European Journal of Pharmacology, 2015. View at Publisher · View at Google Scholar
  • Franck Morceau, Sébastien Chateauvieux, Marion Orsini, Anne Trécul, Mario Dicato, and Marc Diederich, “Natural compounds and pharmaceuticals reprogram leukemia cell differentiation pathways,” Biotechnology Advances, 2015. View at Publisher · View at Google Scholar
  • Chih-Zen Chang, Shu-Chuan Wu, Chih-Lung Lin, and Aij-Lie Kwan, “Valproic acid attenuates intercellular adhesion molecule-1 and E-selectin through a chemokine ligand 5 dependent mechanism and subarachnoid hemorrhage induced vasospasm in a rat model,” Journal of Inflammation, vol. 12, no. 1, 2015. View at Publisher · View at Google Scholar
  • Jaydeep Bhat, Hans-Heinrich Oberg, and Dieter Kabelitz, “Modulation of human gamma/delta T-cell activation and phenotype by histone deacetylase inhibitors,” Cellular Immunology, 2015. View at Publisher · View at Google Scholar
  • Anne Schraplau, Bettina Schewe, Frank Neuschaefer-Rube, Sebastian Ringel, Corinna Neuber, Burkhard Kleuser, and Gerhard P. Pueschel, “Enhanced thyroid hormone breakdown in hepatocytes by mutual induction of the constitutive androstane receptor (CAR, NR1I3) and arylhydrocarbon recepto,” Toxicology, vol. 328, pp. 21–28, 2015. View at Publisher · View at Google Scholar
  • Dominique Bollino, Irina Balan, and Laure Aurelian, “Valproic acid induces neuronal cell death through a novel calpain-dependent necroptosis pathway,” Journal of Neurochemistry, 2015. View at Publisher · View at Google Scholar
  • Torbjörn Tomson, Dina Battino, and Emilio Perucca, “Valproic acid after five decades of use in epilepsy: time to reconsider the indications of a time-honoured drug,” The Lancet Neurology, 2015. View at Publisher · View at Google Scholar
  • Andrix O. Arguelles, Sunitha Meruvu, John D. Bowman, and Mahua Choudhury, “Are epigenetic drugs for diabetes and obesity at our door step?,” Drug Discovery Today, 2015. View at Publisher · View at Google Scholar
  • Cheng Zhang, Jiang F. Zhong, Andres Stucky, Xue-Lian Chen, Michael F. Press, and Xi Zhang, “Histone acetylation: novel target for the treatment of acute lymphoblastic leukemia,” Clinical Epigenetics, vol. 7, no. 1, 2015. View at Publisher · View at Google Scholar
  • Jae Eun Lee, and Jung Hwa Kim, “Valproic acid inhibits the invasion of PC3 prostate cancer cells by upregulating the metastasis suppressor protein NDRG1,” Genetics and Molecular Biology, vol. 38, no. 4, pp. 527–533, 2015. View at Publisher · View at Google Scholar
  • Bushra Parveen, Pillai, Tamboli, and Sayeed Ahmad, “Effect of piperine on pharmacokinetics of sodium valproate in plasma samples of rats using gas chromatography-mass spectrometry method,” Journal of Pharmacy and Bioallied Sciences, vol. 7, no. 4, pp. 317–320, 2015. View at Publisher · View at Google Scholar
  • Rajeev Jain, Manoj Kumar Gupta, Abhishek Chauhan, Vivek Pandey, and Mohana Krishna Reddy Mudiam, “Ultrasound-assisted dispersive liquid–liquid microextraction followed by GC–MS/MS analysis for the determination of valproic acid in urine samples,” Bioanalysis, 2015. View at Publisher · View at Google Scholar
  • Unsal Veli Ustundag, Sevim Tunali, Burcin Alev, Hazal Ipekci, Ebru Emekli-Alturfan, Tugba Tunali Akbay, Refiye Yanardag, and Aysen Yarat, “ Effects of Chard ( B eta Vulgaris  L. Var. Cicla) on Cardiac Damage in Valproic Acid-Induced Toxicity ,” Journal of Food Biochemistry, 2015. View at Publisher · View at Google Scholar
  • Shan-Sen Xu, Ti Zhang, Mei Liu, and Li-Mei Zhao, “The influence of therapeutic drug monitoring compliance on efficiency and safety about valproic acid in epileptic children,” Chinese Pharmaceutical Journal, vol. 50, no. 20, pp. 1829–1832, 2015. View at Publisher · View at Google Scholar
  • Sabbir Khan, Gopabandhu Jena, and Kulbhushan Tikoo, “Sodium valproate ameliorates diabetes-induced fibrosis and renal damage by the inhibition of histone deacetylases in diabetic rat,” Experimental and Molecular Pathology, 2015. View at Publisher · View at Google Scholar
  • Ruturaj R. Masvekar, Nazira El-Hage, Kurt F. Hauser, and Pamela E. Knapp, “GSK3β-activation is a point of convergence for HIV-1 and opiate-mediated interactive neurotoxicity,” Molecular and Cellular Neuroscience, 2015. View at Publisher · View at Google Scholar
  • Sabbir Khan, Gopabandhu Jena, Kulbhushan Tikoo, and Vinod Kumar, “Valproate attenuates the proteinuria, podocyte and renal injury by facilitating autophagy and inactivation of NF-κB/iNOS signaling in diabetic rat,” Biochimie, 2015. View at Publisher · View at Google Scholar
  • Shaista Chaudhary, Pratibha Ganjoo, Sheikh Raiusddin, and Suhel Parvez, “Nephroprotective activities of quercetin with potential relevance to oxidative stress induced by valproic acid,” Protoplasma, vol. 252, no. 1, pp. 209–217, 2015. View at Publisher · View at Google Scholar
  • Xiang-Yu Hou, Jing Jin, Hong-Liarig Li, Rui Liu, Xiao-Mei Fan, and Min Huang, “Valproic acid suppresses SIRT1 inducing hepatotoxicity,” Chinese Pharmacological Bulletin, vol. 31, no. 1, pp. 31–34, 2015. View at Publisher · View at Google Scholar
  • Jesper Kofoed Damm, Sandra Gordon, Mats Jerkeman, Urban Gullberg, Kristina Drott, Mats Ehinger, and Anne Hultquist, “Pharmacologically relevant doses of valproate upregulate CD20 expression in three diffuse large B-cell lymphoma patients in vivo,” Experimental Hematology and Oncology, vol. 4, no. 1, 2015. View at Publisher · View at Google Scholar
  • Dinesh Thotala, Rowan M. Karvas, John A. Engelbach, Joel R. Garbow, Andrew N. Hallahan, Todd A. DeWees, Andrei Laszlo, and Dennis E. Hallahan, “Valproic acid enhances the efficacy of radiation therapy by protecting normal hippocampal neurons and sensitizing malignant glioblastoma cells,” Oncotarget, vol. 6, no. 33, pp. 35004–35022, 2015. View at Publisher · View at Google Scholar
  • Cheng-Lung Hsu, Chia-Hsun Hsieh, Li-Yu Lee, Hung-Ming Wang, Hsin-Pai Li, Yu-Sun Chang, Yung-Chia Kuo, Yenlin Huang, Yin-Cheng Huang, Kar-Wai Lui, Kai-Ping Chang, Tung-Liang Lin, Hsien-Chi Fan, and An-Chi Lin, “Application of a patient-derived xenograft model in cytolytic viral activation therapy for nasopharyngeal carcinoma,” Oncotarget, vol. 6, no. 31, pp. 31323–31334, 2015. View at Publisher · View at Google Scholar
  • Rosa Ana Gonzalez-Polo, Elisa Pizarro-Estrella, Sokhna M. S. Yakhine-Diop, Mario Rodriguez-Arribas, Ruben Gomez-Sanchez, Jose M. Bravo-San Pedro, and Jose M. Fuentes, “Is the Modulation of Autophagy the Future in the Treatment of Neurodegenerative Diseases?,” Current Topics In Medicinal Chemistry, vol. 15, no. 21, pp. 2152–2174, 2015. View at Publisher · View at Google Scholar
  • Michael K. Tso, Elliot Lass, Jinglu Ai, and Loch Macdonald, “Valproic acid treatment after experimental subarachnoid hemorrhage,” Acta Neurochirurgica, Supplementum, vol. 120, pp. 81–85, 2015. View at Publisher · View at Google Scholar
  • Wallach, Colestock, and Adejarepp. 83–107, 2016. View at Publisher · View at Google Scholar
  • Qinghua Xia, Wei Jiang, Zhongxian Huang, Yi Zheng, Muwen Wang, Ronald Rodriguez, and Xunbo Jin, “Valproic acid induces autophagy by suppressing the Akt/mTOR pathway in human prostate cancer cells,” Oncology Letters, vol. 12, no. 3, pp. 1826–1832, 2016. View at Publisher · View at Google Scholar
  • Mohamed Ashraf Khalil, Jan Hraběta, Tomáš Groh, Pavel Procházka, Helena Doktorová, and Tomáš Eckschlager, “Valproic Acid Increases CD133 Positive Cells that Show Low Sensitivity to Cytostatics in Neuroblastoma,” Plos One, vol. 11, no. 9, pp. e0162916, 2016. View at Publisher · View at Google Scholar
  • Sareh Pandamooz, Mohammad Saied Salehi, Mohammad Nabiuni, and Leila Dargahi, “Valproic acid preserves motoneurons following contusion in organotypic spinal cord slice culture,” The Journal of Spinal Cord Medicine, pp. 1–7, 2016. View at Publisher · View at Google Scholar
  • Yaghoub Yazdani, Sima Sedighi, Mehrdad Aghaei, Marie Saghaeian Jazi, Saeed Mohammadi, and Ali Memarian, “Effects of valproic acid and pioglitazone on cell cycle progression and proliferation of T-cell acute lymphoblastic leukemia Jurkat cells,” Iranian Journal of Basic Medical Sciences, vol. 19, no. 7, pp. 779–786, 2016. View at Publisher · View at Google Scholar
  • Naruya Ishizue, Shinichi Niwano, Masanori Saito, Hidehira Fukaya, Hironori Nakamura, Tazuru Igarashi, Tamami Fujiishi, Tomoharu Yoshizawa, Jun Oikawa, Akira Satoh, Jun Kishihara, Masami Murakami, Hiroe Niwano, Hitoshi Miyaoka, and unya Ako, “Polytherapy with Sodium Channel–Blocking Antiepileptic Drugs is Associated with Arrhythmogenic ST-T Abnormality in Patients with Epilepsy,” Seizure, 2016. View at Publisher · View at Google Scholar
  • Dennie G. A. J. Hebels, Axel Rasche, Ralf Herwig, Gerard J. P. van Westen, Danyel G. J. Jennen, and Jos C. S. Kleinjans, “A Systems Biology Approach for Identifying Hepatotoxicant Groups Based on Similarity in Mechanisms of Action and Chemical Structure,” In Silico Methods for Predicting Drug Toxicity, vol. 1425, pp. 339–359, 2016. View at Publisher · View at Google Scholar
  • Yang Sheng, Emily Filichia, Elizabeth Shick, Kenzie L. Preston, Karran A. Phillips, Leslie Cooperman, Zhicheng Lin, Paul Tesar, Barry Hoffer, and Yu Luo, “Using iPSC-derived human DA neurons from opioid-dependent subjects to study dopamine dynamics,” Brain and Behavior, 2016. View at Publisher · View at Google Scholar
  • Bianca A. Torres-Hernández, Luis R. Colón, Coral Rosa-Falero, Aranza Torrado, Nahira Miscalichi, José G. Ortíz, Lorena González-Sepúlveda, Naydi Pérez-Ríos, Erick Suárez-Pérez, John N. Bradsher, and Martine Behra, “Reversal of pentylenetetrazole-altered swimming and neural activity-regulated gene expression in zebrafish larvae by valproic acid and valerian extract,” Psychopharmacology, 2016. View at Publisher · View at Google Scholar
  • Vera L.C.C. Rodrigues, Alberto S. Moraes, Marina B. Felisbino, Maria Luiza S. Mello, Elenice M. Alvarenga, Luisa S. Naves, and Mateus Mondin, “Histone epigenetic marks in heterochromatin and euchromatin of the Chagas' disease vector, Triatoma infestans,” Acta Histochemica, vol. 118, no. 4, pp. 401–412, 2016. View at Publisher · View at Google Scholar
  • Tanveer Singh, and Rajesh Kumar Goel, “Adjuvant indoleamine 2,3-dioxygenase enzyme inhibition for comprehensive management of epilepsy and comorbid depression,” European Journal of Pharmacology, 2016. View at Publisher · View at Google Scholar
  • Gabriele Riva, Valentina Butta, Chiara Cilibrasi, Simona Baronchelli, Serena Redaelli, Leda Dalpra, Marialuisa Lavitrano, and Angela Bentivegna, “Epigenetic targeting of glioma stem cells: Short-term and long-term treatments with valproic acid modulate DNA methylation and differentiation behavio,” Oncology Reports, vol. 35, no. 5, pp. 2811–2824, 2016. View at Publisher · View at Google Scholar
  • Chiara Ciardiello, Luigi Aurisicchio, Rita Mancini, Alessandra Leone, Alessia Noto, Tania Moccia, Carlo Vitagliano, Elena Di Gennaro, Gennaro Ciliberto, Giuseppe Roscilli, Emaluele Marra, Alfredo Budillon, Maria Serena Roca, and Francesca Bruzzese, “Synergistic antitumor activity of histone deacetylase inhibitors and anti-ErbB3 antibody in NSCLC primary cultures via modulation of ErbB receptors expression,” Oncotarget, vol. 7, no. 15, pp. 19559–19574, 2016. View at Publisher · View at Google Scholar
  • Sabbir Khan, and Gopabandhu Jena, “Valproic Acid Improves Glucose Homeostasis by Increasing Beta-Cell Proliferation, Function, and Reducing its Apoptosis through HDAC Inhibition in Juvenile Diabetic Rat,” Journal of Biochemical and Molecular Toxicology, 2016. View at Publisher · View at Google Scholar
  • Jean Xavier, Nadège Bourvis, Antoine Tanet, Tatiana Ramos, Didier Perisse, Isabelle Marey, David Cohen, and Angèle Consoli, “Bipolar Disorder Type 1 in a 17-Year-Old Girl with Wolfram Syndrome,” Journal of Child and Adolescent Psychopharmacology, 2016. View at Publisher · View at Google Scholar
  • Sabbir Khan, Sandeep Kumar, and Gopabandhu Jena, “Valproic acid reduces insulin-resistance, fat deposition and FOXO1-mediated gluconeogenesis in type-2 diabetic rat,” Biochimie, 2016. View at Publisher · View at Google Scholar
  • Lawrence A. Olatunji, Tolulope E. Omolekulo, Taofeek O. Usman, and InKyeom Kim, “Improvement of oral contraceptive-induced glucose dysregulation and dyslipidemia by valproic acid is independent of circulating corticosterone,” Archives of Physiology and Biochemistry, pp. 1–7, 2016. View at Publisher · View at Google Scholar
  • Lichun Sun, Qingqing Qian, Guangchun Sun, L. Vienna Mackey, Joseph A. Fuselier, David H. Coy, and Cui-Yun Yu, “Valproic acid induces NET cell growth arrest and enhances tumor suppression of the receptor-targeted peptide-drug conjugate via activating somatostati,” Journal Of Drug Targeting, vol. 24, no. 2, pp. 169–177, 2016. View at Publisher · View at Google Scholar
  • Manuela Terranova-Barberio, Renato Franco, Alfredo Budillon, Elena Di Gennaro, Maria Serena Roca, Andrea Ilaria Zotti, Alessandra Leone, Francesca Bruzzese, Carlo Vitagliano, Giosuè Scogliamiglio, Domenico Russo, and Giovanni D'Angelo, “Valproic acid potentiates the anticancer activity of capecitabine in vitro and in vivo in breast cancer models via induction of thymidine phosphorylase expression.,” Oncotarget, vol. 7, no. 7, pp. 7715–31, 2016. View at Publisher · View at Google Scholar
  • Ashfaqul Hoque, M. Iqbal Hossain, S. Sadia Ameen, Ching-Seng Ang, Nicholas Williamson, Dominic C.H. Ng, Anderly Chueh, Carli Roulston, and Heung-Chin Cheng, “A beacon of hope in stroke therapy—Blockade of pathologically activated cellular events in excitotoxic neuronal death as potential neuroprotective strategies,” Pharmacology & Therapeutics, 2016. View at Publisher · View at Google Scholar
  • Eleftheriadis, and Stadler, “Long-Term Complete Remission of Cerebral, Pulmonary and Hepatic Metastases by Malignant Melanoma under Fotemustin with Reversible Dementia Syndrome Due to Valproic Acid,” Aktuelle Dermatologie, vol. 42, no. 1-2, pp. 31–34, 2016. View at Publisher · View at Google Scholar
  • Carlota Oleaga, Catia Bernabini, Alec S.T. Smith, Balaji Srinivasan, Max Jackson, William McLamb, Vivien Platt, Richard Bridges, Yunqing Cai, Navaneetha Santhanam, Bonnie Berry, Sarah Najjar, Nesar Akanda, Xiufang Guo, Candace Martin, Gail Ekman, Mandy B. Esch, Jessica Langer, Gladys Ouedraogo, Jose Cotovio, Lionel Breton, Michael L. Shuler, and James J. Hickman, “Multi-Organ toxicity demonstration in a functional human in vitro system composed of four organs,” Scientific Reports, vol. 6, pp. 20030, 2016. View at Publisher · View at Google Scholar
  • Soni, Singh, Patel, Gupta, Srinivas, Patel, and Jha, “A Sensitive Triple Quadrupole Liquid Chromatography Mass Spectrometric Method for the Estimation of Valproic Acid in K2EDTA Human Plasma using Furosemide as the Internal Standard,” Drug Research, vol. 66, no. 12, pp. 666–672, 2016. View at Publisher · View at Google Scholar
  • Mingming Zhao, Ti Zhang, Guofei Li, Feng Qiu, Yaxin Sun, and Limei Zhao, “Simultaneous Determination of Valproic Acid and Its Major Metabolites by UHPLC-MS/MS in Chinese Patients: Application to Therapeutic Drug Monitoring,” Journal of Chromatographic Science, 2016. View at Publisher · View at Google Scholar
  • Elizabeth I. Spehalski, Philip J. Tofilon, and Kevin Camphausen, “Histone Deacetylase Inhibitors and Tumor Radiosensitization,” Increasing the Therapeutic Ratio of Radiotherapy, pp. 57–78, 2016. View at Publisher · View at Google Scholar
  • Ernesta Cavalcanti, Piera Maiolino, Annamaria Trotta, Francesca Bruzzese, Antonio Daponte, Monica Pontone, Francesco Perri, Alfredo Budillon, Franco Ionna, Corrado Aversa, Ettore Pavone, Maria Grazia Maglione, Francesco Caponigro, Antonella Petrillo, Fabio Sandomenico, Roberta D'Aniello, Gerardo Botti, Rossella De Cecio, Nunzia Simona Losito, Stefania Scala, Elena Di Gennaro, Andrea Ilaria Zotti, Ester Calogero, Massimo Montano, Gianfranco De Feo, Francesco Longo, Massimiliano Di Marzo, and Paolo Muto, “Phase II clinical study of valproic acid plus cisplatin and cetuximab in recurrent and/or metastatic squamous cell carcinoma of Head and Neck-V-CHANCE trial,” BMC Cancer, vol. 16, no. 1, 2016. View at Publisher · View at Google Scholar
  • Upendarrao Golla, Deepthi Joseph, and Raghuvir Singh Tomar, “Combined Transcriptomics and Chemical-Genetics Reveal Molecular Mode of Action of Valproic acid, an Anticancer Molecule using Budding Yeast Model,” Scientific Reports, vol. 6, no. 1, 2016. View at Publisher · View at Google Scholar
  • Elerson C. Costalonga, Filipe M. O. Silva, and Irene L. Noronha, “Valproic Acid Prevents Renal Dysfunction and Inflammation in the Ischemia-Reperfusion Injury Model,” BioMed Research International, vol. 2016, pp. 1–10, 2016. View at Publisher · View at Google Scholar
  • Justyna Sosna, Ole Ammerpohl, Dieter Adam, Jaydeep Bhat, Jürgen Fritsch, Elgar Susanne Quabius, Stefan Schütze, Sebastian Zeissig, and Dieter Kabelitz, “Expression of non-secreted IL-4 is associated with HDAC inhibitor-induced cell death, histone acetylation and c-Jun regulation in human gamma/delta T-cells,” Oncotarget, vol. 7, no. 40, pp. 64743–64756, 2016. View at Publisher · View at Google Scholar
  • Hajime Sakuma, Yui Watanabe, Noriko Ii, Shigeki Kobayashi, Yutaka Toyomasu, Tomoko Kawamura, Satoru Ochiai, Yoshihito Nomoto, Yasufumi Yamashita, and Akinori Takada, “Roles of valproic acid in improving radiation therapy for glioblastoma: A review of literature focusing on clinical evidence,” Asian Pacific Journal of Cancer Prevention, vol. 17, no. 2, pp. 463–466, 2016. View at Publisher · View at Google Scholar
  • Elerson C. Costalonga, Luiza J. de Freitas, Deise da S. P. Aragone, Filipe M. O. Silva, and Irene L. Noronha, “Anti-fibrotic effects of valproic acid in experimental peritoneal fibrosis,” Plos One, vol. 12, no. 9, pp. e0184302, 2017. View at Publisher · View at Google Scholar
  • Galina Y. Zheleznyakova, Francesco Marabita, Sabrina Ruhrmann, Eliane Piket, Majid Pahlevan Kakhki, Ewoud Ewing, Maria Needhamsen, Maja Jagodic, and Lara Kular, “Epigenetic research in multiple sclerosis: Progress, challenges, and opportunities,” Physiological Genomics, vol. 49, no. 9, pp. 447–461, 2017. View at Publisher · View at Google Scholar
  • Miao-Miao Zhu, Hui-Lan Li, Li-Hong Shi, Xiao-Ping Chen, Jia Luo, and Zan-Ling Zhang, “The pharmacogenomics of valproic acid,” Journal of Human Genetics, 2017. View at Publisher · View at Google Scholar
  • Timothy P. Bohan, Sean A. Hebert, Christian L. Erikson, and Rita D. Swinford, “Thrombotic microangiopathy associated with Valproic acid toxicity,” BMC Nephrology, vol. 18, no. 1, 2017. View at Publisher · View at Google Scholar
  • Feriha Hadzagic-Catibusic, Edo Hasanbegovic, Melika Melunovic, Smail Zubcevic, and Sajra Uzicanin, “Effects of Carbamazepine and Valproate on Serum Aspartate Aminotransferase, Alanine Aminotransferase and Gamma - Glutamyltransferase in Children.,” Medical archives (Sarajevo, Bosnia and Herzegovina), vol. 71, no. 4, pp. 239–242, 2017. View at Publisher · View at Google Scholar
  • J Choi, S Park, T K Kwon, S I Sohn, K M Park, and J I Kim, “Role of the histone deacetylase inhibitor valproic acid in high-fat diet-induced hypertension via inhibition of HDAC1/angiotensin II axis,” International Journal of Obesity, 2017. View at Publisher · View at Google Scholar
  • Xupeng Bai, Weipeng Hong, Peiheng Cai, Yibei Chen, Chuncao Xu, Di Cao, Weibang Yu, Zhongxiang Zhao, Min Huang, and Jing Jin, “Valproate induced hepatic steatosis by enhanced fatty acid uptake and triglyceride synthesis,” Toxicology and Applied Pharmacology, vol. 324, pp. 12–25, 2017. View at Publisher · View at Google Scholar
  • Isabel Vieira de Assis Lima, Ana Flávia Almeida-Santos, Talita Hélen Ferreira-Vieira, Daniele Cristina Aguiar, Fabíola Mara Ribeiro, Alline Cristina Campos, and Antônio Carlos Pinheiro de Oliveira, “Antidepressant-like effect of valproic acid—Possible involvement of PI3K/Akt/mTOR pathway,” Behavioural Brain Research, vol. 329, pp. 166–171, 2017. View at Publisher · View at Google Scholar
  • Aleksei Rakitin, “Does Valproic Acid Have Potential in the Treatment of Diabetes Mellitus?,” Frontiers in Endocrinology, vol. 8, 2017. View at Publisher · View at Google Scholar
  • Khalil Abnous, Zahra Tayarani-Najaran, Bibi Zahra Khashyarmanesh, Rahman Abdizadeh, Farzin Hadizadeh, Tooba Abdizadeh, Mohammad Reza Kalani, and Razieh Ghodsi, “Design, synthesis and biological evaluation of novel coumarin-based benzamides as potent histone deacetylase inhibitors and anticancer agents,” European Journal of Medicinal Chemistry, vol. 132, pp. 42–62, 2017. View at Publisher · View at Google Scholar
  • Elizabeth A. Thomas, “Histone Posttranslational Modifications in Schizophrenia,” Neuroepigenomics in Aging and Disease, vol. 978, pp. 237–254, 2017. View at Publisher · View at Google Scholar
  • Anna Farrelly-Rosch, Chew Ling Lau, Nitin Patil, Bradley J. Turner, and Fazel Shabanpoor, “Combination of valproic acid and morpholino splice-switching oligonucleotide produces improved outcomes in spinal muscular atrophy patient-derived fibroblasts,” Neurochemistry International, 2017. View at Publisher · View at Google Scholar
  • Hailong Zhang, Wei Zhang, Yong Zhou, Yuhua Jiang, and Shupeng Li, “Dual Functional Mesoporous Silicon Nanoparticles Enhance the Radiosensitivity of VPA in Glioblastoma,” Translational Oncology, vol. 10, no. 2, pp. 229–240, 2017. View at Publisher · View at Google Scholar
  • Johanna E. M. P. Smits, Eveline Wallenburg, Arno Van Spanje, Matthijs Van Luin, and Radboud M. Marijnissen, “Valproate intoxication in a patient with blood valproate levels within therapeutic range,” Journal of Clinical Psychiatry, vol. 78, no. 4, pp. e413–e414, 2017. View at Publisher · View at Google Scholar
  • Lu Lu, Hengxing Zhou, Bin Pan, Xueying Li, Zheng Fu, Jun Liu, Zhongju Shi, Tianci Chu, Zhijian Wei, Guangzhi Ning, and Shiqing Feng, “c-Jun Amino-Terminal Kinase is Involved in Valproic Acid-Mediated Neuronal Differentiation of Mouse Embryonic NSCs and Neurite Outgrowth of NSC-Derived Neurons,” Neurochemical Research, vol. 42, no. 4, pp. 1254–1266, 2017. View at Publisher · View at Google Scholar
  • Zhipeng Wang, Yunlei Yun, Xinfang Xie, Chunhua You, Haijun Miao, Feng Zhang, Shouhong Gao, and Wansheng Chen, “Comparison of LC-MS/MS vs chemiluminescent microparticle immunoassay in measuring the valproic acid concentration in plasma of epilepsy patients in a new perspective,” Journal of Clinical Laboratory Analysis, pp. e22157, 2017. View at Publisher · View at Google Scholar
  • Nazlıhan Aztopal, Merve Erkisa, Elif Erturk, Engin Ulukaya, Asuman Hatice Tokullugil, and Ferda Ari, “Valproic acid, a histone deacetylase inhibitor, induces apoptosis in breast cancer stem cells,” Chemico-Biological Interactions, 2017. View at Publisher · View at Google Scholar
  • Linh N.K. Tran, Ganessan Kichenadasse, Lisa M. Butler, Katherine L. Morel, Rebecca J. Ormsby, Michael Z. Michael, Pamela J. Sykes, Margaret M. Centenera, and Karen M. Lower, “The combination of metformin and valproic acid induces synergistic apoptosis in the presence of p53 and androgen signaling in prostate cancer,” Molecular Cancer Therapeutics, vol. 16, no. 12, pp. 2689–2700, 2017. View at Publisher · View at Google Scholar
  • Marita Eckert, Lukas Klumpp, and Stephan Huber, “Cellular Effects of the Antiepileptic Drug Valproic Acid in Glioblastoma,” Cellular Physiology and Biochemistry, vol. 44, no. 4, pp. 1591–1605, 2017. View at Publisher · View at Google Scholar
  • Manuela Terranova-Barberio, Biagio Pecori, Maria Serena Roca, Serena Imbimbo, Francesca Bruzzese, Alessandra Leone, Paolo Muto, Paolo Delrio, Antonio Avallone, Alfredo Budillon, and Elena Di Gennaro, “Synergistic antitumor interaction between valproic acid, capecitabine and radiotherapy in colorectal cancer: critical role of p53,” Journal of Experimental & Clinical Cancer Research, vol. 36, no. 1, 2017. View at Publisher · View at Google Scholar
  • Vibeke Andresen, and Bjørn T. Gjertsen, “Drug Repurposing for the Treatment of Acute Myeloid Leukemia,” Frontiers in Medicine, vol. 4, 2017. View at Publisher · View at Google Scholar
  • Tooba Abdizadeh, Razieh Ghodsi, and Farzin Hadizadeh, “3d-QSAR (CoMFA, CoMSIA) and molecular docking studies on histone deacetylase 1 selective inhibitors,” Recent Patents on Anti-Cancer Drug Discovery, vol. 12, no. 4, pp. 365–383, 2017. View at Publisher · View at Google Scholar
  • Wenbiao Xiao, Yuze Cao, Hongyu Long, Zhaohui Luo, Shuyu Li, Na Deng, Jianjian Wang, Xiaoyan Lu, Tianfeng Wang, Shangwei Ning, Lihua Wang, and Bo Xiao, “Genome-Wide DNA Methylation Patterns Analysis of Noncoding RNAs in Temporal Lobe Epilepsy Patients,” Molecular Neurobiology, 2017. View at Publisher · View at Google Scholar
  • Jawaher A. Alfurhood, Hao Sun, Christopher P. Kabb, Bryan S. Tucker, James H. Matthews, Hendrik Luesch, and Brent S. Sumerlin, “Poly(N-(2-hydroxypropyl)methacrylamide)–valproic acid conjugates as block copolymer nanocarriers,” Polym. Chem., 2017. View at Publisher · View at Google Scholar
  • Andrea Alpuche-García, Xochitl Dávila-González, Leticia Arregui, and Hiram I. Beltrán, “Novel valproic aminophenol amides with enhanced glial cell viability effect,” RSC Adv., vol. 7, no. 20, pp. 12391–12399, 2017. View at Publisher · View at Google Scholar
  • Fanny Araceli Cabrera-Rivera, Luis Gabriel Hernández-Vázquez, Patricia Flores-Sánchez, Maria Durán-Galván, and Jaime Escalante, “Solvent- and Catalyst-Free Microwave-Assisted Decarboxylation of Malonic Acid Derivatives,” Green and Sustainable Chemistry, vol. 07, no. 04, pp. 270–280, 2017. View at Publisher · View at Google Scholar
  • Hye-Rim Won, Dong Hoon Lee, Hyun-Wook Ryu, and So Hee Kwon, “Advances in epigenetic glioblastoma therapy,” Oncotarget, vol. 8, no. 11, pp. 18577–18589, 2017. View at Publisher · View at Google Scholar
  • Annarita Scialdone, Muhammad Sharif Hasni, Jesper Kofoed Damm, Andreas Lennartsson, Urban Gullberg, and Kristina Drott, “The HDAC inhibitor valproate induces a bivalent status of the CD20 promoter in CLL patients suggesting distinct epigenetic regulation of CD20 expression in CLL in vivo,” Oncotarget, vol. 8, no. 23, pp. 37409–37422, 2017. View at Publisher · View at Google Scholar
  • Mitchell Hadden, and Andrew Advani, “Histone Deacetylase Inhibitors and Diabetic Kidney Disease,” International Journal of Molecular Sciences, vol. 19, no. 9, pp. 2630, 2018. View at Publisher · View at Google Scholar
  • Rashmi R. Shah, and Peter D. Stonier, “Repurposing old drugs in oncology: Opportunities with clinical and regulatory challenges ahead,” Journal of Clinical Pharmacy and Therapeutics, 2018. View at Publisher · View at Google Scholar
  • Santiago G. Lago, and Sabine Bahn, “Clinical Trials and Therapeutic Rationale for Drug Repurposing in Schizophrenia,” ACS Chemical Neuroscience, 2018. View at Publisher · View at Google Scholar
  • Yi-Wen Li, Chung-Hsing Wang, Chao-Jung Chen, Charles C. N. Wang, Cheng-Li Lin, Wai-Kok Cheng, Hsin-Yi Shen, and Yun-Ping Lim, “Effects of antiepileptic drugs on lipogenic gene regulation and hyperlipidemia risk in Taiwan: a nationwide population-based cohort study and supporting in vitro studies,” Archives of Toxicology, 2018. View at Publisher · View at Google Scholar
  • Giulia Iapadre, Ganna Balagura, Luca Zagaroli, Pasquale Striano, and Alberto Verrotti, “Pharmacokinetics and Drug Interaction of Antiepileptic Drugs in Children and Adolescents,” Pediatric Drugs, 2018. View at Publisher · View at Google Scholar
  • Farnaz Barneh, Mona Salimi, Fatemeh Goshadrou, Minoo Ashtiani, Mehdi Mirzaie, Hakimeh Zali, and Mohieddin Jafari, “Valproic acid inhibits the protective effects of stromal cells against chemotherapy in breast cancer: Insights from proteomics and systems biology,” Journal of Cellular Biochemistry, 2018. View at Publisher · View at Google Scholar
  • Kristina Drott, Hans Hagberg, Karin Papworth, Thomas Relander, and Mats Jerkeman, “Valproate in combination with rituximab and CHOP as first-line therapy in diffuse large B-cell lymphoma (VALFRID),” Blood Advances, vol. 2, no. 12, pp. 1386–1392, 2018. View at Publisher · View at Google Scholar
  • Prashant Tripathi, Harilal Patel, Tanuja Kulshrestha, and Nuggehally R Srinivas, “Standard curve range for clinical sample analysis of oral bioavailability/bioequivalence studies: dilemma, introspection and strategies,” Bioanalysis, 2018. View at Publisher · View at Google Scholar
  • Rodrigo M. Da Costa, Karina Karmirian, and Stevens K. Rehen, “Deformation of Mitochondrial Cristae in Human Neural Progenitor Cells Exposed to Valproic Acid,” Anais da Academia Brasileira de Ciências, 2018. View at Publisher · View at Google Scholar
  • Faezeh Jafari, Babak Shirazi Yeganeh, Hossein Niknahad, Reza Heidari, and Forouzan Khodaei, “Mechanism of valproic acid-induced Fanconi syndrome involves mitochondrial dysfunction and oxidative stress in rat kidney,” Nephrology, vol. 23, no. 4, pp. 351–361, 2018. View at Publisher · View at Google Scholar
  • Wenjin Xi, Wei Wang, Tao Wang, Jinbo Sun, Yi Huo, Xu Chen, Guoxu Zheng, Yufang Li, Jieheng Wu, and Angang Yang, “Combined treatment with valproic acid and 5-Aza-2’-deoxycytidine synergistically inhibits human clear cell renal cell carcinoma growth and migration,” Medical Science Monitor, vol. 24, pp. 1034–1043, 2018. View at Publisher · View at Google Scholar
  • Katalin Monostory, Andrea Nagy, Katalin Tóth, Tamás Bűdi, Ádám Kiss, Máté Déri, and Gábor Csukly, “Relevance of CYP2C9 Function in Valproate Therapy,” Current Neuropharmacology, vol. 17, no. 1, pp. 99–106, 2018. View at Publisher · View at Google Scholar
  • Yvonne Eileen Klingl, Ludo Van Den Bosch, Robert Prior, and Lawrence Van Helleputte, “HDAC6 as a potential therapeutic target for peripheral nerve disorders,” Expert Opinion on Therapeutic Targets, vol. 22, no. 12, pp. 993–1007, 2018. View at Publisher · View at Google Scholar
  • Shuo Tian, Ienglam Lei, Wenbin Gao, Liu Liu, Yijing Guo, Jeffery Creech, Todd J. Herron, Shaoxiang Xian, Peter X. Ma, Y. Eugene Chen, Yongqing Li, Hasan B. Alam, and Zhong Wang, “HDAC inhibitor valproic acid protects heart function through Foxm1 pathway after acute myocardial infarction,” EBioMedicine, 2018. View at Publisher · View at Google Scholar
  • Manash P. Borgohain, Krishna Kumar Haridhasapavalan, Chandrima Dey, Poulomi Adhikari, and Rajkumar P. Thummer, “An Insight into DNA-free Reprogramming Approaches to Generate Integration-free Induced Pluripotent Stem Cells for Prospective Biomedical Applications,” Stem Cell Reviews and Reports, 2018. View at Publisher · View at Google Scholar
  • Qing Zhang, Yifan Dai, Zhiming Cai, and Lisha Mou, “HDAC Inhibitors: Novel Immunosuppressants for Allo- and Xeno- Transplantation,” ChemistrySelect, vol. 3, no. 1, pp. 12235–12246, 2018. View at Publisher · View at Google Scholar
  • Katrine M. Johannesen, Elena Gardella, Tarja Linnankivi, Carolina Courage, Anne de Saint Martin, Anna-Elina Lehesjoki, Cyril Mignot, Alexandra Afenjar, Gaetan Lesca, Marie-Thérèse Abi-Warde, Jamel Chelly, Amélie Piton, J. Lawrence Merritt, Lance H. Rodan, Wen-Hann Tan, Lynne M. Bird, Mark Nespeca, Joseph G. Gleeson, Yongjin Yoo, Murim Choi, Jong-Hee Chae, Desiree Czapansky-Beilman, Sara Chadwick Reichert, Manuela Pendziwiat, Judith S. Verhoeven, Helenius J. Schelhaas, Orrin Devinsky, Jakob Christensen, Nicola Specchio, Marina Trivisano, Yvonne G. Weber, Caroline Nava, Boris Keren, Diane Doummar, Elise Schaefer, Sarah Hopkins, Holly Dubbs, Jessica E. Shaw, Laura Pisani, Candace T. Myers, Sha Tang, Shan Tang, Deb K. Pal, John J. Millichap, Gemma L. Carvill, Kathrine L. Helbig, Oriano Mecarelli, Pasquale Striano, Ingo Helbig, Guido Rubboli, Heather C. Mefford, and Rikke S. Møller, “ Defining the phenotypic spectrum of SLC6A1 mutations ,” Epilepsia, 2018. View at Publisher · View at Google Scholar
  • Vinitha Ramanath Pai, Dinesh Upadhya, and Bhuvanesh Sukhlal Kalal, “Valproic acid reduces tumor cell survival and proliferation with inhibitors of downstream molecules of epidermal growth factor receptor pathway,” Journal of Pharmacology and Pharmacotherapeutics, vol. 9, no. 1, pp. 11–16, 2018. View at Publisher · View at Google Scholar
  • Yong-Tao Duan, Jun-Lei Wang, Le Zhao, Ping Lu, Zhi-Juan Zhang, Xiao-Ke Zheng, and Wei-Sheng Feng, “Epigenetic targets and their inhibitors in cancer therapy,” Current Topics in Medicinal Chemistry, vol. 18, no. 28, pp. 2395–2419, 2018. View at Publisher · View at Google Scholar
  • Alchujyan, Kevorkian, Hovhannisyan, Madoyan, Sargsyan, Kevorkian, Chailyan, Movsesyan, Aghababova, Minasyan, and Hairapetyan, “Free and zeolite-immobilized probiotic mixture versus sodium valproate in prevention of oxidative stress and modulation of the l-arginine intracellular metabolic pathways in the rat brain and blood following dexamphetamine- induced bipolar disorder,” European Chemical Bulletin, vol. 7, no. 1, pp. 42–51, 2018. View at Publisher · View at Google Scholar
  • Neel Mehta, Rohit Aiyer, Semih Gungor, and Amitabh Gulati, “A Systematic Review of NMDA Receptor Antagonists for Treatment of Neuropathic Pain in Clinical Practice,” Clinical Journal of Pain, vol. 34, no. 5, pp. 450–467, 2018. View at Publisher · View at Google Scholar
  • Ying Linda Lin, Meir Bialer, Robert M. Cabrera, Richard H. Finnell, and Bogdan J. Wlodarczyk, “Teratogenicity of valproic acid and its constitutional isomer, amide derivative valnoctamide in mice,” Birth Defects Research, 2018. View at Publisher · View at Google Scholar
  • Sunitha Meruvu, John D. Bowman, and Mahua Choudhury, “Healthy Aging and Epigenetic Drugs for Diabetes and Obesity,” Epigenetics of Aging and Longevity, pp. 419–438, 2018. View at Publisher · View at Google Scholar
  • Andrea Méndez, Diego A. Rojas, Carolina A. Ponce, Rebeca Bustamante, Caroll J. Beltrán, Jorge Toledo, Victor A. García-Angulo, Mauricio Henriquez, and Sergio L. Vargas, “Primary infection by Pneumocystis induces Notch-independent Clara cell mucin production in rat distal airways,” Plos One, vol. 14, no. 6, pp. e0217684, 2019. View at Publisher · View at Google Scholar
  • Berker Duman, Kazım Cihan Can, Ece Ağtaş-Ertan, Seyda Erdoğan, Rıfat Serav İlhan, Özlem Doğan, Hakan Kumbasar, and Ulaş Mehmet Çamsarı, “Risk factors for valproic acid induced hyperammonemia and its association with cognitive functions,” General Hospital Psychiatry, 2019. View at Publisher · View at Google Scholar
  • Ganna Balagura, Giulia Iapadre, Alberto Verrotti, and Pasquale Striano, “Moving beyond sodium valproate: choosing the right anti-epileptic drug in children,” Expert Opinion on Pharmacotherapy, pp. 1–8, 2019. View at Publisher · View at Google Scholar
  • Tadafumi Kato, “Current understanding of bipolar disorder: Toward integration of biological basis and treatment strategies,” Psychiatry and Clinical Neurosciences, 2019. View at Publisher · View at Google Scholar
  • Rodolfo Soria-Castro, Alejandro Schcolnik-Cabrera, Gloria Rodríguez-López, Marcia Campillo-Navarro, Nahum Puebla-Osorio, Sergio Estrada-Parra, Iris Estrada-García, Rommel Chacón-Salinas, and Alma D. Chávez-Blanco, “Exploring the Drug Repurposing Versatility of Valproic Acid as a Multifunctional Regulator of Innate and Adaptive Immune Cells,” Journal of Immunology Research, vol. 2019, pp. 1–24, 2019. View at Publisher · View at Google Scholar
  • Diana Balasubramanian, John F. Pearson, and Martin A. Kennedy, “Gene expression effects of lithium and valproic acid in a serotonergic cell line,” Physiological Genomics, vol. 51, no. 2, pp. 43–50, 2019. View at Publisher · View at Google Scholar
  • Serkalem Mekonnen, “Valproic Acid Poisoning,” Journal of Emergency Nursing, vol. 45, no. 1, pp. 98–100, 2019. View at Publisher · View at Google Scholar
  • Rashmi R. Shah, “Safety and Tolerability of Histone Deacetylase (HDAC) Inhibitors in Oncology,” Drug Safety, 2019. View at Publisher · View at Google Scholar
  • Lihong Shi, Miaomiao Zhu, Huilan Li, Zhipeng Wen, Xiaoping Chen, Jia Luo, Cong Lin, and Zanling Zhang, “SCN1A and SCN2A polymorphisms are associated with response to valproic acid in Chinese epilepsy patients,” European Journal of Clinical Pharmacology, 2019. View at Publisher · View at Google Scholar
  • Anusara Aranarochana, Pornthip Chaisawang, Apiwat Sirichoat, Wanassanun Pannangrong, Peter Wigmore, and Jariya Umka Welbat, “Protective effects of melatonin against valproic acid-induced memory impairments and reductions in adult rat hippocampal neurogenesis,” Neuroscience, 2019. View at Publisher · View at Google Scholar