BioMed Research International / 2010 / Article / Tab 3

Research Article

Testosterone Depletion by Castration May Protect Mice from Heat-Induced Multiple Organ Damage and Lethality

Table 3

Mean (±SEM) of neuronal damage score values in hypothalamus for different groups of mice.

Treatment groupsNeuronal damage score

(1) Normothermic controls (NCs)0 (0, 0)
(2) Sham-operated, vehicle-treated heatstroke (SOH) mice 2 ( 2 , 2 )
(3) Castrated, vehicle-treated heatstroke (CVH) mice 0 ( 0 , 0 . 2 5 )
(4) Castrated, testosterone-treated heatstroke (CTH) mice 1 ( 1 , 1 )

* 𝑃 < . 0 5 in comparison to group 1; ** 𝑃 < . 0 5 in comparison to group 2;
*** 𝑃 < . 0 5 in comparison to group 3. Vehicle or testosterone was administered 14 days before whole body heating (WBH), and the tissue section was obtained for neuronal damage score assay 2.5 h post-WBH. Data are means ± SEM of 7 mice per group

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