Testosterone Depletion by Castration May Protect Mice from Heat-Induced Multiple Organ Damage and Lethality

Table 3

Mean (±SEM) of neuronal damage score values in hypothalamus for different groups of mice.

Treatment groups	Neuronal damage score
(1) Normothermic controls (NCs)	0 (0, 0)
(2) Sham-operated, vehicle-treated heatstroke (SOH) mice	2(2,2)^∗
(3) Castrated, vehicle-treated heatstroke (CVH) mice	0(0,0.25)^∗∗
(4) Castrated, testosterone-treated heatstroke (CTH) mice	1(1,1)^∗∗∗

* 𝑃<.05 in comparison to group 1; **𝑃<.05 in comparison to group 2;
*** 𝑃<.05 in comparison to group 3. Vehicle or testosterone was administered 14 days before whole body heating (WBH), and the tissue section was obtained for neuronal damage score assay 2.5 h post-WBH. Data are means ± SEM of 7 mice per group