Regression of Human Prostate Tumors and Metastases in Nude Mice following Treatment with the Recombinant Oncolytic Vaccinia Virus GLV-1h68

Table 1

Distribution of GLV-1h68 in tissues of PC-3 tumor-bearing nude mice at day 42 after virus injection.

Tissue/Organ* (pfu/g)	Female and male mice
Lung (𝑛=4 )	2.76×10^3±8.4×10^2
Lymph node (𝑛=8)	2.93×10^3±1.9×10^3
Tumor (𝑛=4)	1.69×10^6±5.27×10^5
Spleen	n.d.

*All mice were sacrificed 42 days after virus injection. The data were determined by a standard plaque assay on CV-1 cells using aliquots of the homogenized organs and were displayed as mean pfu/g.
For each organ, two aliquots of 0.1 mL were measured in triplicates. n.d.: not detectable.