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Journal of Biomedicine and Biotechnology
Volume 2010, Article ID 513803, 9 pages
Research Article

Combining Microdialysis and Near-Infrared Spectroscopy for Studying Effects of Low-Load Repetitive Work on the Intramuscular Chemistry in Trapezius Myalgia

1Centre for Musculoskeletal Research, University of Gävle, P.O. Box 7629, S-907 12 Umeå, Sweden
2Department of Surgical and Perioperative Sciences, Sports Medicine Unit, Umeå University, S-901 87 Umeå, Sweden
3Institute of Health and Society, Medical Faculty Baddiley-Clark building, Newcastle University, Richardson Road, Newcastle Upon Tyne, NE2 4AX, UK
4Department of Community Medicine and Rehabilitation, Rehabilitation Medicine, Umeå University, S-901 87 Umeå, Sweden

Received 1 February 2010; Revised 31 March 2010; Accepted 31 March 2010

Academic Editor: Guy M. Benian

Copyright © 2010 Gerd M. Flodgren et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Epidemiological research provides strong evidence for a link between repetitive work (RW) and the development of chronic trapezius myalgia (TM). The aims were to further elucidate if an accumulation of sensitising substances or impaired oxygenation is evident in painful muscles during RW. Females with TM ( ) were studied during rest, 30 minutes RW and 60 minutes recovery. Microdialysate samples were obtained to determine changes in intramuscular microdialysate (IMMD) [glutamate], [PG ], [lactate], and [pyruvate] (i.e., [concentration]) relative to work. Muscle oxygenation (%St ) was assessed using near-infrared spectroscopy. During work, all investigated substances, except PG , increased significantly: [glutamate] (54%, ), [lactate] (26%, ), [pyruvate] (19%, ), while the %St decreased ( ). During recovery [PG ] decreased ( ), [lactate] remained increased ( ), [pyruvate] increased progressively ( ), and %St had returned to baseline. Changes in substance concentrations and oxygenation in response to work indicate normal increase in metabolism but no ongoing inflammation in subjects with TM.