BioMed Research International

Research Article

Decrease of Klotho in the Kidney of Streptozotocin-Induced Diabetic Rats

Table 1

Changes in blood glucose, BUN, and creatinine levels in streptozotocin-induced diabetic rats (STZ-DN) receiving repeated i.p. injection with insulin (1 IU/kg) or phloridzin (1 mg/kg) three times per day for 7 days.
Normal rats-vehicleSTZ-DN-vehicleSTZ-DN-InsulinSTZ-DN-Phloridzin
BeforeAfterBeforeAfterBeforeAfterBeforeAfter
Glucose (mg/dL) 1 1 8 . 3 ± 1 2 . 1 1 2 1 . 8 ± 1 0 . 7 4 6 8 . 4 ± 1 1 a 4 7 3 . 1 ± 6 . 2 a 4 5 5 . 8 ± 1 0 . 3 2 4 4 . 3 ± 8 . 4 b 4 8 8 . 3 ± 1 4 . 4 2 1 3 . 4 ± 1 2 . 7 b
BUN (mg/dL) 1 8 . 9 ± 0 . 4 1 9 . 1 ± 0 . 8 3 4 . 3 ± 0 . 4 a 3 8 . 2 ± 1 . 1 a , b 3 4 . 6 ± 1 . 8 2 3 . 8 ± 0 . 9 b 3 2 . 6 ± 1 . 3 2 4 . 5 ± 1 . 4 b
Creatinine ( 𝜇 g/dL) 6 1 2 . 3 ± 1 1 . 2 6 0 5 . 4 ± 9 . 8 7 1 7 . 8 ± 1 1 . 6 a 7 4 4 . 2 ± 3 . 9 a 7 8 7 . 2 ± 1 4 . 7 6 7 4 . 2 ± 8 . 6 b 8 1 7 . 6 ± 2 6 . 5 6 3 4 . 9 ± 1 1 . 7 b
Values (mean ± SE) were obtained from each group of six rats. The vehicle used to dissolve the testing drugs was given at the same volume. a 𝑃 < . 0 5 —for values obtained from STZ-DN group compared to the values obtained from vehicle-treated normal rats. b 𝑃 < . 0 5 —for values after treatment compared to the values of before vehicle, insulin or phloridzin treatment, respectively.