Regulation of P-Glycoprotein in Renal Proximal Tubule Epithelial Cells by LPS and TNF-α
Figure 3
Lack of involvement of cGMP and PKC in P-gp regulation. ((a) ) P-gp transport activity in GERP cells after exposure to 10 ng/mL TNF-α in combination with 10 M of the sGC inhibitor ODQ for 24 hours compared to control (cells exposed to culture medium). ((b) ) P-gp transport activity in GERP cells after exposure to 10 ng/mL TNF-α in combination with 100 nM of the PKC inhibitor BIM for 24 hours compared to control. Data are expressed as mean SEM. Significantly different compared to control (: ; : ). Treatment with ODQ or BIM alone showed no significant difference compared to control.
