Research Article

A Styrene-alt-Maleic Acid Copolymer Is an Effective Inhibitor of R5 and X4 Human Immunodeficiency Virus Type 1 Infection

Table 1

alt-PSMA and PSS activity (IC50/IC90) against clinical isolates of various subtypes.

Virus identifier (subtype) a , b
93MW965 (C)SM145 (C)KNH1144 (A)KNH1207 (A)US1 (B)

PSMA0.009/0.030.006/0.050.005/0.020.003/0.020.003/0.009
PSS0.003/0.20.004/0.30.02/0.090.02/0.030.02/0.09

a All viruses were characterized as R5, as described in the NIH AIDS Research and Reference Reagent Program datasheets.
b Antiviral activities are expressed as IC50/IC90 concentrations (mg/mL).