Research Article

iTRAQ Quantitative Analysis of Multidrug Resistance Mechanisms in Human Gastric Cancer Cells

Table 1

iTRAQ analysis of differentially expressed proteins between vincristine-resistant SGC7901/VCR (iTRAQ 121) and SGC7901 (iTRAQ 119).

𝑁 AccessionGene symbolName121  :  119 𝑃 -value 121  :  119Function

1IPI  :  IPI00013214.2MCM3DNA replication licensing factor MCM30.38.03Hydrolase
2IPI  :  IPI00218831.4GSTM1Glutathione S-transferase Mu 10.41.02Transferase
3IPI  :  IPI00293276.10MIFMacrophage migration inhibitory factor0.42.05Calcium binding protein
4IPI  :  IPI00025277.5PDCD6Programmed cell death protein 60.42.00Calcium binding protein
5IPI  :  IPI00873768.1NEDD8Putative uncharacterized protein NEDD8 (Fragment)0.42.04Nucleic acid binding
6IPI  :  IPI00017617.1DDX5Probable ATP-dependent RNA helicase DDX50.45.02Nucleic acid binding
7IPI  :  IPI00887678.1PPIAPeptidyl-prolyl cis-trans isomerase A0.52.00Chaperones
8IPI  :  IPI00013679.1DUTIsoform 1 of Deoxyuridine 5 -triphosphate nucleotidohydrolase, mitochondrial0.530.01Hydrolase
9IPI  :  IPI00453473.6HIST4H4Histone H40.53.01Nucleic acid binding
10IPI  :  IPI00794659.1RPS2040S ribosomal protein S200.56.01Nucleic acid binding
11IPI  :  IPI00441498.1FOLR1Folate receptor alpha0.57.00Transporter
12IPI  :  IPI00003348.3GNB2Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-20.59.02Hydrolase
13IPI  :  IPI00027497.5GPIGlucose-6-phosphate isomerase0.61.00Hydrolase
14IPI  :  IPI00216953.1LMNAIsoform ADelta10 of Lamin-A/C0.61.01Cytoskeletal protein
15IPI  :  IPI00472171.3RPL760S ribosomal protein L70.62.04Nucleic acid binding
16IPI  :  IPI00419833.8HIST1H2BLHistone H2B type 1-L0.62.01Nucleic acid binding
17IPI  :  IPI00746438.2RPL11Isoform 2 of 60S ribosomal protein L110.62.01Nucleic acid binding
18IPI  :  IPI00219910.2BLVRBFlavin reductase0.64.04Oxidoreductase
19IPI  :  IPI00024915.2PRDX5Isoform Mitochondrial of Peroxiredoxin-5, mitochondrial0.64.03Oxidoreductase
20IPI  :  IPI00304596.3NONONon-POU domain-containing octamer-binding protein0.65.04Nucleic acid binding
21IPI  :  IPI00219217.3LDHBL-lactate dehydrogenase B chain0.66.04Oxidoreductase
22IPI  :  IPI00872107.1ILF2Interleukin enhancer binding factor 2 variant (Fragment)0.66.03Nucleic acid binding
23IPI  :  IPI00329801.12ANXA5ANXA5 Annexin A50.66.02Calcium binding protein
24IPI  :  IPI00299024.9BASP1Brain acid soluble protein 10.67.01Signaling molecule
25IPI  :  IPI00479186.6PKM2Isoform M1 of Pyruvate kinase isozymes M1/M20.67.03Kinase
26IPI  :  IPI00382470.3HSP90AA1Hsp89-alpha-delta-N0.69.01Chaperones
27IPI  :  IPI00217966.8LDHAL-lactate dehydrogenase A chain0.700.03Oxidoreductase
28IPI  :  IPI00220362.5HSPE110 kDa heat shock protein, mitochondrial0.71.04Chaperones
29IPI  :  IPI00027463.1S100A6S100A6 Protein S100-A60.72.03Calcium binding protein
30IPI  :  IPI00553185.2CCT3T-complex protein 1 subunit gamma0.720.01Chaperones
31IPI  :  IPI00873403.1RPL2460S ribosomal protein L240.74.01Nucleic acid binding
32IPI  :  IPI00003918.6RPL460S ribosomal protein L40.74.03Nucleic acid binding
33IPI  :  IPI00216298.6TXNThioredoxin0.74.02Oxidoreductase
34IPI  :  IPI00472119.2RPS3A40S ribosomal protein S3a0.75.01Nucleic acid binding
35IPI  :  IPI00014898.3PLEC1Isoform 1 of Plectin-10.76.00Cytoskeletal protein
36IPI  :  IPI00784154.1HSPD1 60 kDa heat shock protein, mitochondrial1.32.00Chaperones
37IPI  :  IPI00301311.1SETIsoform 2 of Protein SET1.32.00Signaling molecule
38IPI  :  IPI00646512.1RBBP7Histone-binding protein RBBP71.33.03Nucleic acid binding
39IPI  :  IPI00168849.3TRIP10Isoform 1 of Cdc42-interacting protein 41.33.03Cytoskeletal protein
40IPI  :  IPI00856098.1RRBP1Isoform 1 of Ribosome-binding protein 11.33.01Extracellular matrix
41IPI  :  IPI00026216.4NPEPPSPuromycin-sensitive aminopeptidase1.34.03Protease
42IPI  :  IPI00298547.3PARK7Protein DJ-11.35.00Nucleic acid binding
43IPI  :  IPI00420014.2SNRNPIsoform 1 of U5 small nuclear ribonucleoprotein 200 kDa helicase1.35.03Nucleic acid binding
44IPI  :  IPI00396485.3EEF1A1Elongation factor 1-alpha 11.36.00Nucleic acid binding
45IPI  :  IPI00645208.3FUSIsoform Short of RNA-binding protein FUS1.37.01Nucleic acid binding
46IPI  :  IPI00879160.1RANBP1Ran-specific GTPase-activating protein1.38.01Signaling molecule
47IPI  :  IPI00029079.5GMPSGMP synthase [glutamine-hydrolyzing]1.38.02Transferase
48IPI  :  IPI00019502.3MYH9Isoform 1 of Myosin-91.38.00Cytoskeletal protein
49IPI  :  IPI00009904.1PDIA4Protein disulfide-isomerase A41.39.03Isomerase
50IPI  :  IPI00186290.6EEF2Elongation factor 21.39.01Nucleic acid binding
51IPI  :  IPI00438229.2TRIM28Isoform 1 of Transcription intermediary factor 1-beta1.39.01Nucleic acid binding
52IPI  :  IPI00333541.6FLNAIsoform 1 of Filamin-A1.40.00Cytoskeletal protein
53IPI  :  IPI00022228.2HDLBPVigilin1.40.01Transporter
54IPI  :  IPI00747237.1NOP16HSPC1851.40.04Signaling molecule
55IPI  :  IPI00012197.1DCTPP1XTP3-transactivated gene A protein1.41.04Extracellular matrix
56IPI  :  IPI00025252.1PDIA3Protein disulfide-isomerase A31.41.00Isomerase
57IPI  :  IPI00304925.5HSPA1BHeat shock 70 kDa protein 11.42.02Chaperones
58IPI  :  IPI00219622.3PSMA2Proteasome subunit alpha type-21.42.00Protease
59IPI  :  IPI00395646.1TXNDC5MUTED thioredoxin domain containing 5 isoform 21.43.02Isomerase
60IPI  :  IPI00147874.1NANSSialic acid synthase1.44.02Synthase
61IPI  :  IPI00021812.2AHNAKNeuroblast differentiation-associated protein AHNAK1.44.00Signaling molecule
62IPI  :  IPI00789285.1TXNDC17Thioredoxin domain-containing protein 171.45.01Isomerase
63IPI  :  IPI00020599.1CALRCalreticulin1.46.03Calcium binding protein
64IPI  :  IPI00007926.1C6orf108c-Myc-responsive protein Rcl1.46.01Signaling molecule
65IPI  :  IPI00101037.3RCN3Reticulocalbin-31.48.01Calcium binding protein
66IPI  :  IPI00307162.2VCLIsoform 2 of Vinculin1.48.01Cytoskeletal protein
67IPI  :  IPI00017726.1HSD17B10Isoform 1 of 3-hydroxyacyl-CoA dehydrogenase type-21.48.00Oxidoreductase
68IPI  :  IPI00645078.1UBA1Ubiquitin-like modifier-activating enzyme 11.49.02Signaling molecule
69IPI  :  IPI00844348.1PON2paraoxonase 2 isoform 11.51.01Hydrolase
70IPI  :  IPI00719669.4MRLC2Myosin regulatory light chain1.53.01Cytoskeletal protein
71IPI  :  IPI00000105.4MVPMajor vault protein1.53.00Nucleic acid binding
72IPI  :  IPI00000873.3VARSValyl-tRNA synthetase1.54.05Synthase
73IPI  :  IPI00871312.1NUDCPutative uncharacterized protein NUDC (Fragment)1.55.01Cytoskeletal protein
74IPI  :  IPI00215637.5DDX3XATP-dependent RNA helicase DDX3X1.56.02Nucleic acid binding
75IPI  :  IPI00873622.2WDR1Putative uncharacterized protein WDR11.58.00Cytoskeletal protein
76IPI  :  IPI00011937.1PRDX4Peroxiredoxin-41.62.00Oxidoreductase
77IPI  :  IPI00409590.1LMO7Isoform 1 of LIM domain only protein 71.64.01Cytoskeletal protein
78IPI  :  IPI00022793.5HADHBTrifunctional enzyme subunit beta, mitochondrial1.65.01Transferase
79IPI  :  IPI00884896.1TXNRD1Isoform 1 of Thioredoxin reductase 1, cytoplasmic1.67.03Oxidoreductase
80IPI  :  IPI00020632.4ASS1Argininosuccinate synthase1.73.00Synthase
81IPI  :  IPI00795408.1RPL2360S ribosomal protein L231.74.01Nucleic acid binding
82IPI  :  IPI00218343.4TUBA1CTubulin alpha-1C chain1.82.02Cytoskeletal protein
83IPI  :  IPI00027223.2IDH1Isocitrate dehydrogenase [NADP] cytoplasmic1.82.01Oxidoreductase
84IPI  :  IPI00015018.1PPA1Inorganic pyrophosphatase1.98.00Hydrolase
85IPI  :  IPI00910593.1CNN2Calponin-22.00.01Cytoskeletal protein
86IPI  :  IPI00014424.1EEF1A2Elongation factor 1-alpha 22.05.00Nucleic acid binding
87IPI  :  IPI00220642.7YWHAG14-3-3 protein gamma2.07.01Chaperones
88IPI  :  IPI00745868.3ANXA3 Putative uncharacterized protein ANXA3 (Fragment)2.37.01Calcium binding protein
89IPI  :  IPI00025512.2HSPB1Heat shock protein beta-12.69.00Chaperones
90IPI  :  IPI00027481.1ABCB1Multidrug resistance protein 14.38.02Transporter
91IPI  :  IPI00414264.2SRIsorcin isoform b4.90.00Calcium binding protein