BioMed Research International

Research Article

Absorption, Distribution, Excretion, and Pharmacokinetics of -Pyronaridine Tetraphosphate in Male and Female Sprague-Dawley Rats

Table 2

Tissue pharmacokinetic parameters in male Sprague-Dawley rats after administration of a single oral dose of 10 mg/kg of 14C-PNDP ( 𝑛 = 6 , Mean±S.D.).
Tissues 𝐶 m a x 𝑇 m a x 𝑡 1 / 2 A U C 2 4 0 h r A U C i n f
( 𝜇 g/g)(hr)(hr)( 𝜇 g ⋅ hr/g)( 𝜇 g ⋅ hr/g)
Brain 6 . 7 ± 1 . 8 3 1 . 3 ± 6 . 5 1 6 0 . 2 ± 1 6 5 . 3 7 8 . 1 ± 1 5 . 4 1 7 1 . 2 ± 6 5 . 5
Lung 3 6 . 4 ± 4 . 6 1 0 . 7 ± 6 . 5 1 0 9 . 0 ± 1 9 . 7 2 5 7 3 . 6 ± 2 0 1 . 9 3 0 0 6 . 6 ± 2 4 6 . 2
Heart 1 0 . 1 ± 1 . 5 1 0 . 7 ± 6 . 5 2 0 0 . 6 ± 3 7 . 9 7 1 3 . 8 ± 1 0 4 . 3 9 0 1 . 6 ± 1 7 0 . 4
Liver 1 8 6 . 8 ± 1 8 . 9 4 . 7 ± 1 . 6 2 1 6 . 4 ± 4 6 . 8 4 1 6 7 . 5 ± 5 5 7 . 3 8 1 0 7 . 2 ± 9 6 9 . 1
Spleen 8 8 . 0 ± 1 4 . 9 4 4 . 0 ± 4 9 . 0 1 2 5 . 7 ± 3 0 . 3 1 0 0 5 . 3 ± 2 2 4 . 1 1 3 6 7 . 7 ± 3 3 4 . 7
Kidney 5 3 . 6 ± 1 2 . 7 2 1 . 3 ± 6 . 5 1 1 1 . 8 ± 1 7 . 9 4 4 1 . 6 ± 4 4 . 2 5 5 7 . 3 ± 9 4 . 8
Stomach 4 7 . 9 ± 1 3 . 6 1 . 0 ± 0 . 0 1 2 9 . 1 ± 3 7 . 1 5 3 5 . 3 ± 1 2 . 8 7 0 0 . 9 ± 6 2 . 5
Small intestine 1 6 6 . 3 ± 1 5 . 5 2 . 0 ± 1 . 5 1 4 2 . 6 ± 7 3 . 6 2 1 8 1 . 8 ± 2 5 1 . 3 2 5 3 2 . 7 ± 5 0 5 . 5
Large intestine 1 7 . 5 ± 4 . 7 1 6 . 0 ± 8 . 8 1 0 5 . 0 ± 2 9 . 8 1 0 6 3 . 8 ± 8 3 . 5 1 2 6 5 . 6 ± 9 4 . 9