BioMed Research International

Research Article

Absorption, Distribution, Excretion, and Pharmacokinetics of -Pyronaridine Tetraphosphate in Male and Female Sprague-Dawley Rats

Table 3

Tissue pharmacokinetic parameters in female Sprague-Dawley rats after administration of a single oral dose of 10 mg/kg of 14C-PNDP ( 𝑛 = 6 , Mean±S.D.).
Tissues 𝐶 m a x 𝑇 m a x 𝑡 1 / 2 A U C 2 4 0 h r A U C i n f
( 𝜇 g/g)(hr)(hr)( 𝜇 g ⋅ hr/g)( 𝜇 g ⋅ hr/g)
Brain 8 . 2 ± 2 . 7 3 6 . 7 ± 2 8 . 4 1 8 4 . 3 ± 1 1 1 . 2 1 0 7 . 1 ± 2 2 . 5 1 7 6 . 5 ± 2 8 . 9
Lung 4 1 . 9 ± 5 . 4 8 . 0 ± 0 . 0 1 2 0 . 3 ± 2 6 . 9 3 0 3 3 . 5 ± 3 2 4 . 6 4 1 2 3 . 0 ± 4 0 0 . 3
Heart 7 . 9 ± 1 . 0 7 . 3 ± 1 . 6 1 9 8 . 5 ± 5 3 . 9 7 0 0 . 6 ± 1 4 7 . 8 1 2 6 7 . 9 ± 2 7 9 . 8
Liver 1 8 9 . 8 ± 8 . 1 4 . 7 ± 1 . 6 2 1 8 . 4 ± 7 4 . 0 4 9 1 9 . 1 ± 3 4 2 . 2 8 8 8 7 . 8 ± 8 9 4 . 9
Spleen 7 6 . 6 ± 7 . 0 4 2 . 3 ± 5 . 6 1 1 8 . 9 ± 5 5 . 1 1 2 5 7 . 6 ± 5 0 9 . 9 2 4 8 3 . 6 ± 5 3 6 . 8
Kidney 3 1 . 0 ± 2 . 8 8 . 0 ± 1 . 2 1 4 4 . 2 ± 1 7 . 5 3 7 2 . 5 ± 2 0 . 9 5 7 2 . 3 ± 6 0 . 9
Stomach 3 0 . 7 ± 1 1 . 8 1 . 0 ± 0 . 4 1 2 7 . 0 ± 2 7 . 9 6 2 3 . 2 ± 4 6 . 5 8 3 5 . 6 ± 4 9 . 7
Small intestine 1 8 6 . 1 ± 1 2 . 2 4 . 0 ± 1 . 2 1 6 6 . 6 ± 1 6 . 3 3 4 7 9 . 4 ± 1 7 3 . 6 3 7 9 3 . 5 ± 3 0 9 . 8
Large intestine 2 3 . 9 ± 2 . 8 1 8 . 0 ± 2 . 3 9 9 . 8 ± 2 9 . 6 1 5 5 6 . 5 ± 1 2 5 . 6 2 0 7 8 . 4 ± 5 3 9 . 9