BioMed Research International / 2010 / Article / Tab 4

Research Article

Absorption, Distribution, Excretion, and Pharmacokinetics of -Pyronaridine Tetraphosphate in Male and Female Sprague-Dawley Rats

Table 4

Mean percentage cumulative recovery of total radioactivity over 240 hours post administration of a single oral dose of 10 mg/kg of 14C-PNDP.

Mean percentage radioactive dose
Male SD-rat (%)Female SD-rat (%)

Faeces 5 . 0 ± 0 . 7 6 . 5 ± 1 . 6
Urine 4 9 . 9 ± 3 . 5 4 7 . 6 ± 6 . 2
Cage rinse 0 . 5 ± 0 . 1 0 . 4 ± 0 . 1
CO2 1 . 0 ± 0 . 2 1 . 1 ± 0 . 1
Carcass 1 2 . 7 ± 1 . 0 1 3 . 1 ± 2 . 0
Tissues 1 7 . 1 ± 1 . 5 1 8 . 9 ± 1 . 2
Blood 1 3 . 2 ± 1 . 3 1 2 . 2 ± 1 . 1

Total 9 9 . 4 ± 2 . 9 9 9 . 8 ± 2 . 5

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