Absorption, Distribution, Excretion, and Pharmacokinetics of ^𝟏𝟒C-Pyronaridine Tetraphosphate in Male and Female Sprague-Dawley Rats

Table 4

Mean percentage cumulative recovery of total radioactivity over 240 hours post administration of a single oral dose of 10 mg/kg of ¹⁴C-PNDP.

	Mean percentage radioactive dose
	Male SD-rat (%)	Female SD-rat (%)
Faeces	5.0±0.7	6.5±1.6
Urine	49.9±3.5	47.6±6.2
Cage rinse	0.5±0.1	0.4±0.1
CO2	1.0±0.2	1.1±0.1
Carcass	12.7±1.0	13.1±2.0
Tissues	17.1±1.5	18.9±1.2
Blood	13.2±1.3	12.2±1.1
Total	99.4±2.9	99.8±2.5