Osteogenic Activity of Locally Applied Small Molecule Drugs in a Rat Femur Defect Model

Table 1

Summary of Animal Disposition.

		Postsurgical
Treatment versus Blank	Initial Group Size	Morbidity & Mortality				Histology Error	Group Size for Each Analysis
		Fracture	Infection	Anesthesia	Other		microCT	Histomorph.
Empty Defect	6	0	0	0	1	0	5	5
Low-Dose Alendronate	6	1 (Rx)	1	0	0	1	4	3
High-Dose Alendronate	6	1 (Rx)	0	0	0	0	5	5
Low-Dose Lovastatin	6	0	0	0	0	0	6	6
High-Dose Lovastatin	7	0	0	1	0	0	6	6
Low-Dose Omeprazole	6	0	0	0	0	0	6	6
High-Dose Omeprazole	8	1 (Bl )	0	1	0	1	6	5
Totals	45	3	1	2	1	2	38	35