A Pivotal Role for Interleukin-27 in CD8⁺ T Cell Functions and Generation of Cytotoxic T Lymphocytes

Figure 1

The IL-6/IL-12 heterodimeric cytokine family. IL-27 plays pivotal roles as a pro-inflammatory cytokine to promote the early induction of Th1 differentiation and also as an anti-inflammatory cytokine to limit the T cell hyperactivity and production of pro-inflammatory cytokines.