Antinociceptive and Toxicological Effects of Dioclea grandiflora Seed Pod in Mice

Table 2

Effect of EDgP on formalin-induced licking in mice.

Treatment	Dose	Paw licking (s)
	(mg/kg, i.p.)	Early phase (0–5 minutes)	Inhibition (%)	Late phase (15–30 minutes)	Inhibition (%)
Control (10 mL/kg i.p.)		85.8 ± 7.6		233.9 ± 23.6
D. grandiflora	75	46.6 ± 6.5*	45.7	44.0 ± 27.5*	81.2
	150	35.5 ± 5.3*	58.6	0.0 ± 0.0*	100
	300	43.5 ± 5.0*	49.3	29.0 ± 27.9*	87.6
Morphine	10	33.5 ± 4.6*	61.0	60.7 ± 24.8*	74.0
Naloxone	6
+
D. grandiflora	300	47.1 ± 4.3*	45.1	4.9 ± 4.9*	97.9
Morphine	10	69.2 ± 8.0	19.3	246.3 ± 30.5	0

Values are mean ± S.E.M. (𝑛=10). ^∗𝑃<.001 versus control, Bonferroni test.