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Journal of Biomedicine and Biotechnology
Volume 2010 (2010), Article ID 645213, 10 pages
Research Article

-Glucan Oligosaccharide Enhances T Cells Immune Response Induced by a DNA Vaccine Encoding Hepatitis B Virus Core Antigen

1Key laboratory of Medical Molecular Virology of Ministries of Education and Health, Institute of Medical Microbiology and Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032, China
2Department of Pharmacology of Chinese Materia Medica, China Pharmaceutical University, Nanjing 210038, China
3Department of Biochemistry and Molecular Biology, Shanghai Medical College, Fudan University, Shanghai 200032, China
4State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
5Laboratory of Cytokines, Unit of Immunobiology, Institute of Biomedical Technologies, National Research Council, 56124 Pisa, Italy

Received 30 November 2009; Revised 27 February 2010; Accepted 29 March 2010

Academic Editor: Zhengguo Xiao

Copyright © 2010 Jing Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Online Supplemental Material includes effect of β-glu6 on pB144-induced recruitment of T cells. The recruitment of CD4+ T cells in the liver and peripheral blood of mice immunized by pB144 with β-glu6 is shown in the Supplementary Figure 1. The number of CD8+ T cells in the liver and peripheral blood is illustrated in Supplementary Figure 2.

  1. Supplementary Material