Figure 4: Decreased expression of key proteins in the dystrophin-deficient MDX heart. Shown are expanded views of 2-D gels of normal versus dystrophic MDX heart tissue. Shown are the AK1 isoform of adenylate kinase, ATP synthase, DJ1-protein, fatty acid binding protein FABP3, porin isoform VDAC1, stress protein Hsp60, isocitrate dehydrogenase (ICDH), myosin light chain MLC2, succinate dehydrogenase (SDH) and prohibitin. The position of 2-D spots representing distinct mitochondrial proteins is indicated by arrowheads on the right.