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Journal of Biomedicine and Biotechnology
Volume 2010 (2010), Article ID 690925, 7 pages
Research Article

Reconstruction of Protein-Protein Interaction Network of Insulin Signaling in Homo Sapiens

Department of Chemical Engineering, Boğaziçi University, 34342 Bebek-İstanbul, Turkey

Received 21 April 2010; Revised 22 July 2010; Accepted 27 October 2010

Academic Editor: Sorin Draghici

Copyright © 2010 Saliha Durmuş Tekir et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Diabetes is one of the most prevalent diseases in the world. Type 1 diabetes is characterized by the failure of synthesizing and secreting of insulin because of destroyed pancreatic β-cells. Type 2 diabetes, on the other hand, is described by the decreased synthesis and secretion of insulin because of the defect in pancreatic β-cells as well as by the failure of responding to insulin because of malfunctioning of insulin signaling. In order to understand the signaling mechanisms of responding to insulin, it is necessary to identify all components in the insulin signaling network. Here, an interaction network consisting of proteins that have statistically high probability of being biologically related to insulin signaling in Homo sapiens was reconstructed by integrating Gene Ontology (GO) annotations and interactome data. Furthermore, within this reconstructed network, interacting proteins which mediate the signal from insulin hormone to glucose transportation were identified using linear paths. The identification of key components functioning in insulin action on glucose metabolism is crucial for the efforts of preventing and treating type 2 diabetes mellitus.