Modulation of Muscle Atrophy, Fatigue and MLC Phosphorylation by MuRF1 as Indicated by Hindlimb Suspension Studies on MuRF1-KO Mice
Figure 1
MuRF1 protein expression and hindlimb suspension. MuRF1 protein expression was monitored in tibialis cranialis (TC) and soleus (Sol.) muscles before (co; control), after unloading by hindlimb suspension (ul), and after reloading (rl). MuRF1 expression was compared relative to alpha-tubulin (a) or actin (b) as a control for loading and blotting. Low levels of MuRF1 protein were detected in control TC and Sol.; MuRF1 was severalfold elevated after unloading by hindlimb suspension in both muscle types and returned to nearly normal expression levels after 5 days of reloading (rl).
