Phenotypic Transition of the Collecting Duct Epithelium in Congenital Urinary Tract Obstruction

Figure 2

Histological features of human fetal obstructive nephropathy. Obstructed 18 weeks gestation kidney shows disorganized cortical architecture with multiple glomerular cysts (c), decreased glomerular (g) endowment ((b) and (f)), and reduced number and dilation of the collecting ducts (cd) in the hypoplastic medulla ((d) and (h)). Cortex ((a) and (e)) and medulla ((c) and (g)) of a normal 18-week gestation kidney. (a)–(d): hematoxylin and eosin stain; (e)–(h) immunofluorescence histochemistry: green = cytokeratin, red = vimentin. Scale bar = 100 𝜇m.

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