The Role of Genetic Variation Near Interferon-Kappa in Systemic Lupus Erythematosus
Figure 4
Serum type I IFN levels in SLE patients stratified by IFNK genotype. Serum type I IFN activity in European (a) and African-American (b) ancestry SLE patients is shown, stratified by genotype at the associated SNP in each ancestral background. Minor allele homozygotes are combined with the heterozygous state in each case due to low numbers. Serum type I IFN activity is reported in relative units (see methods for derivation of IFN activity). Data are nonnormally distributed, so the box-and-whiskers format is used, with lines indicating the median, boxes showing the interquartile range, and error bars showing the 10th and 90th percentiles. values were calculated using a nonparametric Mann-Whitney test.
