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Journal of Biomedicine and Biotechnology
Volume 2010, Article ID 715295, 15 pages
http://dx.doi.org/10.1155/2010/715295
Review Article

DNA-Based Applications in Nanobiotechnology

King Abdullah Institute for Nanotechnology and Centre of Excellence in Biotechnology, King Saud University, P.O. Box 2454, Riyadh 11451, Saudi Arabia

Received 20 August 2009; Revised 4 March 2010; Accepted 18 April 2010

Academic Editor: John B. Vincent

Copyright © 2010 Khalid M. Abu-Salah et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Biological molecules such as deoxyribonucleic acid (DNA) have shown great potential in fabrication and construction of nanostructures and devices. The very properties that make DNA so effective as genetic material also make it a very suitable molecule for programmed self-assembly. The use of DNA to assemble metals or semiconducting particles has been extended to construct metallic nanowires and functionalized nanotubes. This paper highlights some important aspects of conjugating the unique physical properties of dots or wires with the remarkable recognition capabilities of DNA which could lead to miniaturizing biological electronics and optical devices, including biosensors and probes. Attempts to use DNA-based nanocarriers for gene delivery are discussed. In addition, the ecological advantages and risks of nanotechnology including DNA-based nanobiotechnology are evaluated.