Aberrant Methylation of Thrombospondin-1 and Its Association with Reduced Expression in Gastric Cardia Adenocarcinoma

Table 1

Methylation status, immunohistochemical staining characteristics of TSP1, and immunohistochemical staining characteristics of TGF-𝛽1 in GCA patients

	Methylation			Protein			Protein
Group	status of TSP1		𝑃	expression of TSP1		𝑃	expression of TGF-𝛽1		𝑃
	M	U		−	+		−	+
TNM stage
I	1	6		0	7		5	2
II	9	26		7	28		20	15
III	16	23		14	25		17	22
IV	8	7	.036^a	6	9	.028^a	4	11	.045^a
Pathological differentiation of tumor
Well	13	30		10	33		29	14
Moderate	13	22		10	25		14	21
Poor	8	10	.551^b	7	11	.463^b	3	15	.001^b

^a𝑃 value of stage III and IV patients against stage I and II patients, ^b𝑃 value among three differentiation groups.