Review Article
Antigen-Specific Polyclonal Cytotoxic T Lymphocytes Induced by Fusions of Dendritic Cells and Tumor Cells
Table 1
Assessment of DCs/tumor fusions based vaccine.
| | Patients | DCs/tumor fusions | Coadministration | Clinical responses | Ref. | | Dendritic cells | Tumor cells |
| | Melanoma () | Allogeneic | Autologous | | 1 (CR) | [98] | | | | | 1 (PR) | | | | | | 5 (SD) | | | | | | 9 (PD) | |
| | Glioma () | Autologous | Autologous | | 2 (PR) | [101] | | | | | 1 (SD) | | | | | | 5 (PD) | |
| | Melanoma () | Autologous | Autologous | | 1 (PR) | [99] | | | | | 1 (SD) | | | | | | 15 (PD) | |
| | Melanoma () | Allogeneic | Autologous | rh IL-2 | 1 (SD) | [100] | | | | | 10 (PD) | |
| | Glioma () | Autologous | Autologous | rh IL-12 | 3 (PR) | [100] | | | | | 2 (MR) | | | | | | 4 (SD) | | | | | | 3 (PD) | |
| | Breast cancer () | Autologous | Autologous | rh IL-12 | 1 (SD) | [100] | | | | | 1 (PD) | |
| | Gastric/Colorectal cancer () | Autologous | Autologous | rh IL-12 | 1 (SD) | [100] | | | | | 2 (PD) | |
| | Ovarian cancer () | Autologous | Autologous | rh IL-12 | 2 (SD) | [100] | | | | | 1 (PD) | |
| | Melanoma () | Autologous | Autologous | rh IL-12 | 4 (PD) | [100] |
| | Breast cancer () | Autologous | Autologous | | 2 (PR) | [21] | | | | | 1 (SD) | | | | | | 7 (PD) | |
| | Renal cell carcinoma () | Allogeneic | Autologous | | 2 (PR) | [22] | | | | | 8 (SD) | | | | | | 10 (PD) | |
| | Hepatocellular carcinoma () | Autologous | Autologous | | 1 (PD) | [88] |
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CR: complete response; PR: partial response; MR: mixed response; SD: stable disease; PD: progressive disease.
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