Review Article

Epidermal Growth Factor (EGF) Treatment on Multipotential Stromal Cells (MSCs). Possible Enhancement of Therapeutic Potential of MSC

Figure 3

Simplified model for the effects of EGFR/ErbB1 signaling on MSC osteogenic differentiation. Weak and temporal stimulation of EGFR/ErbB1 exerts anti-osteogenic effects, whereas strong and sustained stimulation of EGFR/ErbB1 exerts pro-osteogenic effects on MSC.
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