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Journal of Biomedicine and Biotechnology
Volume 2010 (2010), Article ID 846872, 17 pages
Review Article

Tumor Microenvironment and Immune Effects of Antineoplastic Therapy in Lymphoproliferative Syndromes

1Pathology Department, Hospital de Tortosa Verge de la Cinta, c/Esplanetes 14, 41300 Tortosa, Spain
2Clinical Oncology Department, Hospital Universitario Virgen Macarena, Avda Dr Fedriani s/n, 41009 Sevilla, Spain
3Pathology Department, Hospital Universitario Virgen Macarena, Avda Dr Fedriani s/n, 41009 Sevilla, Spain
4Clinical Oncology Department, Hospital Universitario Puerta de Hierro, c/Manuel de Falla 1, 28222 Madrid, Spain

Received 28 December 2009; Revised 14 May 2010; Accepted 21 June 2010

Academic Editor: Zhengguo Xiao

Copyright © 2010 Tomás Álvaro et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Lymphomas represent a wide group of heterogenic diseases with different biological and clinical behavior. The underlying microenvironment-specific composition seems to play an essential role in this scenario, harboring the ability to develop successful immune responses or, on the contrary, leading to immune evasion and even promotion of tumor growth. Depending on surrounding lymphoid infiltrates, lymphomas may have different prognosis. Moreover, recent evidences have emerged that confer a significant impact of main lymphoma's treatment over microenvironment, with clinical consequences. In this review, we summarize these concepts from a pathological and clinical perspective. Also, the state of the art of lymphoma's anti-idiotype vaccine development is revised, highlighting the situations where this strategy has proven to be successful and eventual clues to obtain better results in the future.