Research Article

Expressions of Neuregulin 1 and ErbB4 in Prefrontal Cortex and Hippocampus of a Rat Schizophrenia Model Induced by Chronic MK-801 Administration

Table 1

Immunoreactivity of NRG1 𝛽 and ErbB4 in the rat prefrontal cortex and hippocampal subregions.

VehicleMK-801

PFCNRG1 𝛽 Cg1 and M2 1 0 0 ± 6 . 1 2 1 0 1 . 8 4 ± 6 . 6 9
PrL 1 0 0 ± 4 . 7 9 1 0 8 . 7 5 ± 5 . 0 9
ErbB4Cg1 and M2 1 0 0 ± 7 . 9 6 1 2 5 . 3 3 ± 7 . 4 5
PrL 1 0 0 ± 6 . 0 8 1 3 5 . 0 9 ± 8 . 0 3

HCNRG1 𝛽 CA1 1 0 0 ± 1 0 . 7 9 2 0 4 . 0 8 ± 1 0 . 8 7
CA3 1 0 0 ± 7 . 6 9 1 4 2 . 9 2 ± 6 . 3 9
DG 1 0 0 ± 1 0 . 2 9 1 6 7 . 1 8 ± 1 1 . 0 2
ErbB4CA1 1 0 0 . 0 0 ± 6 . 2 8 1 4 0 . 2 3 ± 8 . 6 6
CA3 1 0 0 . 0 0 ± 4 . 8 7 1 0 6 . 2 7 ± 5 . 9 4
DG 1 0 0 . 0 0 ± 7 . 4 8 1 0 6 . 3 2 ± 7 . 0 4

PFC: prefrontal cortex; HC: hippocampus; Cg1: cingulate cortex area 1; M2: secondary motor cortex; PrL: prelimbic cortex; DG: dentate gyrus.
𝑃 < . 0 5 compared to vehicle group.