Review Article

Challenges for Biomarker Discovery in Body Fluids Using SELDI-TOF-MS

Figure 3

Protein mass spectra collected on CM10 and I M A C - C u 2 + ProteinChip arrays with serum samples provided by five patients with arthritidies (including rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis) and five noninflammatory controls (NIC) (including osteoarthritis). (a) The inflammatory-related proteins S100A8, S100A12, S100A9, and one of its variant S 1 0 0 A 9 āˆ— are arthritis biomarkers detected on CM10 arrays. (b) On I M A C - C u 2 + ProteinChip arrays, SAA and its 2 variants (SAA-R and SAA-RS) are illustrated, reproduced from [19].
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(a)
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(b)