Could CD4 Capture by T Cells Play a Role in HIV Spreading?
Figure 1
Human CD8+ CTL specific for the cytomegalovirus N9V Ag capture CD4 from T2 target cells. Human CD8+ T cells were incubated for 1 hour with T2 cells, which express CD4 and HLA-A2.1 naturally, that had been loaded (Ag) or not (Ag) with the N9V peptide. Cells were then analyzed by flow cytometry for CD4 and CD8 expression. Shown are overlapping histograms of CD4 expression on gated CD8+ T cells. Similar results were obtained in 3 experiments.
