Antinociceptive Activity of Melicope ptelefolia Ethanolic Extract in Experimental Animals

Table 1

The effect of the M. ptelefolia ethanolic extract (MPEE) on the hot-plate test in mice. Results are expressed as the mean ± S.E.M. in seconds of 6 mice. **𝑃<.01 compared to the control group (Dunnet’s test).

Treatment	Dose (mg/kg; p.o.)	Interval following treatment (min)
		0	30	60	90	120	180	210
		Latency time (s)
Control (0.9% NaCl)		7.9±1.3	6.9±1.3	7.8±1.35	8.8±1.3	8.3±0.9	8.8±1.8	9.1±1.4
MPEE	30	6.8±0.8	6.9±0.3	7.0±1.0	7.5±1.1	7.2±0.7	8.1±1.5	8.3±2.0
	100	7.5±1.6	8.0±1.3	8.1±1.3	9.2±0.8	10.2±2.1	10.4±2.8	11.1±2.4
	300	7.4±2.4	8.8±1.6	8.3±1.8	10.8±1.5	9.7±2.1	9.9±2.5	8.5±1.8
Morphine	5	8.0±1.1	15.9±1.2 **	17.8±2.7 **	14.3±2.2 **	12.6±3.4 **	10.9±4.0	10.9±1.2