Antinociceptive Activity of Melicope ptelefolia Ethanolic Extract in Experimental Animals

Table 2

The effect of the M. ptelefolia ethanolic extract (MPEE) on the rota-rod test in mice. Results are expressed as the mean ± S.E.M. in seconds of 6 mice. **𝑃<.01 compared to the control group (Dunnet’s test).

Treatment	Dose (mg/kg)	Interval following treatment (min)
		30	60	120
		Time of permanence (s)/60 s
Control (0.9% NaCl)		60	60	59.3±0.3
MPEE (p.o.)	30	60	59.8±0.9	58.9±0.5
	100	59.8±0.4	59.8±0.4	59.6±0.2
	300	59.2±0.5	57.9±0.6	58.6±0.6
Diazepam (i.p.)	4	37.6±8.9 **	32.5±2.2 **	39.6±1.7 **