Quantitative Proteomics Analysis of Maternal Plasma in Down Syndrome Pregnancies Using Isobaric Tagging Reagent (iTRAQ)

Table 3

List of the protein identified as down regulated from the iTRAQ experiment, indicating is the biological process and molecular function of these proteins. (P value .001).

No.	Acc. number	%Cov	Protein name	Biological processes	Molecular functions
1	P01009	32.8	Alpha-1-antitrypsin	Nerve-nerve synaptic transmission	Glutamate receptor
2	P02768	67	Serum albumin	Amino acid biosynthesis	Reductase
3	P63261	49.1	Actin, cytoplasmic 2 (Gamma-actin)	Cell structure	Actin and actin related protein
4	O95445	32.4	Apolipoprotein M (Apo-M)	Lipid transport	Plasma protein
5	P06727	67.7	Apolipoprotein A-IV	Lipid and fatty acid transport	Transporter
6	P02775	41.4	Platelet basic protein	Pyrimidine metabolism	Phosphorylase
7	P02647	85.8	Apolipoprotein A-I	Lipid and fatty acid transport	Transporter
8	P01023	39.8	Alpha-2-macroglobulin	Developmental processes	Serine/threonine kinase
9	P02787	58.9	Serotransferrin	Amino acid biosynthesis	Synthase
10	P04275	11.3	von Willebrand factor	Cell adhesion	Extracellular matrix glycoprotein
11	P02671	35.2	Fibrinogen alpha chain	Cell proliferation and differentiation	Extracellular matrix glycoprotein
12	P01024	29.6	Complement C3	Nerve-nerve synaptic transmission	Glutamate receptor
13	P98160	5.1	Heparan sulfate proteoglycan	Extracellular matrix	Cell adhesion mediated signal
14	P51884	33.4	Lumican	Receptor	Cell adhesion-mediated signaling
15	P04114	41.5	Apolipoprotein B-100	Lipid and fatty acid transport	Component of serum lipoproteins
16	Q8WZ42	9.5	Titin (EC 2.7.11.1) (Connectin)	Muscle contraction	Actin binding cytoskeletal protein
17	P08519	11	Apolipoprotein(a)	Cell proliferation and differentiation	Peptide hormone
18	P43652	47.7	Afamin	Transport	Other transfer/carrier protein
19	P06396	54.9	Gelsolin	Cell structure	Nonmotor actin binding protein
20	P02749	54.2	Beta-2-glycoprotein 1	Amino acid metabolism	Transaminase
21	Q9NYC9	4.8	Dynein heavy chain 9	Force generating protein	ATPase activity
22	P32119	4	Peroxiredoxin-2	Redox regulation	Eliminating peroxides