The Structure and Function of Serum Opacity Factor: A Unique Streptococcal Virulence Determinant That Targets High-Density Lipoproteins

Figure 2

A schematic indicating the location of functional domains within SOF. The yellow segments in the top bar indicate regions of SOF that are highly variable (vary in ≥60% of serotypes), black segments indicate highly conserved regions of SOF (conserved in ≥60% of serotypes. Only SOFs from S. pyogenes were used to generate this illustration. There are variations in the size of SOF from different serotypes but most are composed of ∼1050 amino acids including the leader sequence. The black lines signify the general location and size of the indicated domains. Abbreviations: vWFA: von Willebrand Factor A domain, MIDAS: metal ion-dependent adhesion site, Fn/Fgn: fibronectin/fibrinogen.