Review Article

The Structure and Function of Serum Opacity Factor: A Unique Streptococcal Virulence Determinant That Targets High-Density Lipoproteins

Table 2

Prevalence of SOF among various bacteria.

BacteriaNumber of strains positive for SOF/ t o t a l a Reference

Group A streptococcus S. pyogenes 52/117, 77/125, 51/93[22, 77, 78]
Group B streptococcus S. agalactiae 0/14, 0/30, 5/18[75, 76],
Group C streptococcus S. equi 4/15, 0/20[75, 76]
Group D streptococcus S. bovis, S. equinus, Enterococcus faecalis b 0/3[76]
Group F streptococcus S. 𝑎 𝑛 𝑔 𝑖 𝑛 𝑜 𝑠 𝑢 𝑠 c 2/5, 0/5 [75, 76]
Group G streptococcus S. dysgalactiae, S. arginosus, S. canis 20/20, 37/68, 0/36 [29, 75, 76]
Group R streptococcus S. suis 3 3 / 3 6 d [30]
Staphylococcus aureus0/5
Staphylococcus epidermidis3/3[79]

a p o s i t i v e for sof gene and/or for opacification of serum by extracts
b f o r m e r l y   Streptococcus faecalis
c f o r m e r l y   S. milleri, it is a heterogeneous group that may also express group A, C F, or G antigens.
d a p p r o x i m a t e l y 70% of the 33 contained a nonfunctional sof gene.
u n p u b l i s h e d results from Courtney et al.