Review Article
Genetically Modified Mouse Models Used for Studying the Role of the AT2 Receptor in Cardiac Hypertrophy and Heart Failure
Table 1
Cardiac phenotype and function in mice with AT2 overexpression (TG) or knock out (KO).
| Mouse model | Strain | Baseline | Disease state | References |
| | | ↔HW/BW | AS: ↔ HW/BW | | AT2 TG mice (cardiomyocyte-specific, α-MHC) | C57BL/6 | ↑PW | Ang II: ↔ HW/BW, ↓HR | [15, 18, 19] | | | ↑EF% | MI: ↔LVMI, ↑PW, ↑EF% | |
| | | | ↑LVW/BW, | | | | | | ↓wall thickness | | | | | | ↑interstitial collagen | | | | TG | | ↑myocyte area and length | | [14] | AT2 TG mice (ventricular myocyte-specific, MLC-2v) | | | ↓LV contractile function | | | | FVB/n | ↑apoptosis | | | | | | AS: ↔LVW/BW | | | | | | ↔wall thickness | | | | | | ↓myocyte diameter | | | TG | | ↔ cardiac morphology and function | ↓interstitial collagen | [21] | | | | | ↓LVSP | | | | | | ↓LVEDP | |
| | | | ↑BP | AS: No hypertrophy | | | | | ↑HR | ↓interstitial collagen | | | | | ↓LVW/BW | ↔cardiac function | | AT2 KO mice | | C57BL/6 | ↓wall thickness | Ang II: No hypertrophy | [16, 22, 23] | | | | ↓LVMI | ↔BP | | | | | ↔contractile function | ↓interstitial collagen | | | | | | ↑diastolic function | |
| | | | ↔BP | AS: ↔hypertrophy | | | | | ↔ cardiac morphology | ↑perivascular fibrosis | | AT2 KO mice | | FVB/n | | ↑coronary arterial thickening | | | | | | AMI: ↑LVW/BW | [17, 24, 25] | | | | | ↑Lung/BW | | | | | | ↓EF% | |
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HW: heart weight; LVW: left ventricular weight; BP: blood pressure; HR: heart rate; LVMI: left ventricular mass index; PW: posterior wall thickness; EF: ejection fraction; AS: aortic stenosis; Ang II: Ang II infusion; MI: myocardial infarction.
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