Beyond Histone and Deacetylase: An Overview of Cytoplasmic Histone Deacetylases and Their Nonhistone Substrates

Table 2

Subcellular localization and functions of nonhistone substrates of HDAC4 and HDAC7.

Histone deacetylases	Substrates	Localization of substrates	Functions	Comments
HDAC4	p53	Nucleus	Increases repressional activity of p53	Under DNA damage conditions
	Runx2	Nucleus	Promotes Smurf-mediated degradation of Runx2
	MLP	Cytoplasm	Regulation of muscle contraction in cardiac mechanical stretch
	HIF1α	Cytoplasm	Cytoplasmic retention to maintain neuronal survival
	DNAJB8	Cytoplasm	Suppression of cytotoxic protein aggregation
HDAC7	HIF1α	Nucleus	Corepressor for HIF1α	Deacetylation is not confirmed for this interaction