Cardiac Imaging Using Clinical 1.5 T MRI Scanners in a Murine Ischemia/Reperfusion Model

Table 2

Cardiac functional parameters. Fractional shortening (FS) determined by echocardiography and cine magnetic resonance imaging (MRI), fractional area change (FAC) determined by cine magnetic resonance imaging. Values shown as mean percentage ± standard deviation before (preop), 24 h and 1 week after ischemia/reperfusion procedure for mice with no ischemia (sham), 30 min or 60 min of ischemia during procedure. Troponin T levels (ng/ml) are shown for each group. *Significant difference to sham-operated mice; ^†Significant difference to 60 min operated mice; all 𝑃<.05.

	0 min = sham	30 min	60 min
FS echo preop (%)	50.8±3.7	50.5±3.1	51.5±3.6
FS MRI preop (%)	48.2±5.1	47.5±5.3	47.4±3.6
FAC preop (%)	55.5±5.4	55.7±6.3	52.5±2.7
FS echo 24 h (%)	51±5.5^†	41.1±5.6^∗	40.7±3.6^∗
FS MRI 24 h (%)	45.8±8.6^†	33.1±9.7^∗	26.2±4.6^∗
FAC 24 h (%)	55.3±6.9^†	42.8±6.9^∗	38.6±3.6^∗
FS echo 1 W (%)	55.3±1.6^†	43.2±4.2^∗,†	37.7±5.9^∗
FS MRI 1 W (%)	50.7±2.4^†	39.1±5.4^∗,†	32.2±10.2^∗
FAC 1 W (%)	59.6±6.1^†	46.4±2.8^∗,†	36.9±8.8^∗
Troponin T (ng/ml)	0.1±0.1	2.4±0.7^∗	3.8±2.0^∗