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Journal of Biomedicine and Biotechnology
Volume 2011, Article ID 187103, 14 pages
Review Article

Sex Differences in Drug Disposition

1Departments of Oncology, Georgetown University Medical Center, Washington, DC 20057, USA
2Departments of Medicine, Physiology, Obstetrics and Gynecology, Georgetown University Medical Center, Washington, DC 20057, USA
3Lombardi Comprehensive Cancer Center, LL, S-166, Georgetown University Medical Center, 3800 Reservoir Road, N.W., Washington, DC 20057, USA
4Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Rockville, MD 20852-3902, USA

Received 29 October 2010; Revised 20 December 2010; Accepted 5 January 2011

Academic Editor: Stelvio M. Bandiera

Copyright © 2011 Offie P. Soldin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Physiological, hormonal, and genetic differences between males and females affect the prevalence, incidence, and severity of diseases and responses to therapy. Understanding these differences is important for designing safe and effective treatments. This paper summarizes sex differences that impact drug disposition and includes a general comparison of clinical pharmacology as it applies to men and women.