Sex Differences in Drug Disposition

Table 2

Sex differences in plasma binding.

Compound	Description
Testosterone	Plasma protein binding: F > M, Estrogen increases
Chlordiazepoxide	Plasma protein binding: M > F > Foc
Diazepam	Free fraction: Foc (1.99%) > F (1.67%) > M (1.46%)
Lidocaine	Free fraction: F (34%), M (32%) < Foc (37%)
Warfarin	Free fraction: F > M
Morphine, Phenytoin Oxazepam, Lorazepam	No differences

oc: oral contraceptives.
Table modified from Soldin and Mattison [5].