Table 1: Different phenotypes of inbred mouse strains with diet- or genetically induced obesity (summary of references [50, 74, 75]).

StrainCharacteristicsCrossed with obese mice, and so forth

C57BL/6JHigh-fat diet-induced diabetes and obesity [119]Lepob/ob mice exhibit obesity but not diabetes [120]
C57BLKS/JHigh-fat diet-induced diabetes and obesity weaker than C57BL/6J [49]Lepob/ob mice exhibit obesity with severe diabetes [120]
DBA/2More glucose tolerance than C57BL/6 on a high-fat diet [121]Lepob/ob mice exhibit obesity with severe diabetes [122]
129svLow insulin; more glucose tolerance than other strains on a high-fat diet [123]Homozygous for db allele db3J mice display mild/transient hyperglycemia with marked hyperinsulinemia and develop hypoglycemia leading to sudden death [124]
BTBRAbdominal obesity with peripheral, but not hepatic insulin resistance [125]Lepob/ob mice exhibit obesity with severe diabetes [126]
A/JLow glucose level even on a high-fat diet; obesity and diabetes-resistant [119, 127, 128]Not reported
BALB/cSimilar to A/J; glucose tolerance [121]Lepob/ob mice exhibit reduced adiposity and increased thermogenesis and are fertile [129]
C3HHigh glucose tolerance with robust insulin secretion [121]Not reported
AKRSensitive to diet-induced obesity with hyperinsulinemia and insulin resistance [48]Not reported
CAST/EiLean at 12 weeks on a high-fat diet [130]Not reported
Nonobese Diabetic45% fat diet-induced transient hyperglycemia with severe obesity [75]Not reported
New Zealand ObeseResemble metabolic syndrome in humans; high-fat diet-induced obesity and hyperglycemia [24, 25]Not reported
FVBHigh glucose levels with lower levels of insulin on normal chow [75]Leprdb/db mice display insulin resistance, severe hyperglycemia, and marked hyperinsulinemia compared to C57BL/6 [131]
Kuo KondoObesity; hyperleptinemia; increased glucose and HbA1c; hyperinsulinemia similar to C57BLKS/J Leprdb/db mice [30]Ay mutation in agouti results in frank diabetes with nephropathy [34]
TallyHoNatural model of obesity with type 2 diabetes [132]Not reported
Nagoya-Shibata-YasudaExhibit obesity; all males and 1/3 of females exhibit glucose intolerance [133]Not reported
ALS/LtSensitive to alloxan-induced diabetes [134]Introduction of Ay mutation induces diabetes in 100% of males and 60% of females at 24 weeks of age [135]
M16Increased body weight, fat and food intake; both males and females develop hyperinsulinemia; only males develop moderate hyperglycemia [29]Not reported
LG and SMHigh-fat diet-stimulated body weight gain and increased plasma glucose more in SM than LG mice [136]Not reported
Tsumura, Suzuki, Obese DiabetesObesity and moderate diabetes [26, 27]Not reported
AkitaMutation in insulin 2 gene; nonobese [137]Not reported