The Structural Basis of Ligand Recognition by Natural Killer Cell Receptors

Figure 7

Structure of CD94 and associated complexes. (a) CD94 monomer shown in cartoon representation. (b) NKG2A/CD94 heterodimer structure with NKG2A shown in light blue and CD94 shown in green cartoon representation with each α-helix from both molecules colored red. (c) NKG2A shown in cartoon representation rotated 90° in relation to (7B) displaying interacting residues in ball and stick representation. Residues colored in green are part of interaction region 1 described in the text while residues colored salmon are part of region 2 also described in the text. (d) CD94 in cartoon representation rotated 90° in relation to (B) with residues colored yellow part of interaction region 1 while residues colored in grey are part of interaction region 2. (e) Cartoon representation of NKG2A/CD94 in complex with peptide bound HLA-E molecule. The bound peptide is shown in ball and stick representation with off-white carbon atoms (f) HLA-E molecule rotated 90° from (7E) illustrating the HLA-E interaction surface with residues which form bonds with NKG2A and CD94 shown in light blue coloring, and green coloring, respectively. Bound peptide is also shown in ball and stick representation. (g) NKG2A/CD94 molecule rotated 90° from (7E) showing the HLA-E interaction surface with the bound peptide shown for reference, residues which interact with HLA-E and the peptide are shown colored green in ball and stick representation.