Review Article

Mouse Models of Escherichia coli O157:H7 Infection and Shiga Toxin Injection

Table 1

Commonly used mouse models of STEC colonization and/or disease.

ModelInoculum (CFU)Inoculation MethodFeaturesHistopathologySource

Str-treated1010FeedingColonization, morbidity, mortality with 933cu-revKidney[79]
Str-treated (O91:H21)LD50 < 10FeedingColonization, morbidity, mortalityKidney[94]
MMC & str (O157:H-)>109 (M)aIGColonization, morbidity, mortalityKidney, brain[95]
Conventional107, 108IGMorbidity, mortalityKidney, intestines[76]
Germfree2 × 102 (C)a,
2 × 109 (D, M)a
IGColonization, morbidity, mortalityKidney, intestines, brain[96]
PCM2 × 105–2 × 107IGColonization, morbidity, mortalityKidney, intestines, brain[77]
Conventional~2 × 1010IGColonization[97]
Germfree5 × 107IGColonization, morbidity, Mortality with hypertoxigenic strainKidney, intestines, brain[98]
Conventional1011/kgIGColonization[99]
MMC & str5 × 103IGColonization, morbidity, mortalityKidney, other[78]
Germfree102–106IGColonization, morbidity, mortalityKidney[75]
Conventional (weaned)6 × 109/kgIGMorbidity and mortalityKidney, intestines[100]

aC: colonization, D: disease, M: mortality.