Synthesis and Evaluation of Amino Acid-Based Radiotracer ^99mTc-N4-AMT for Breast Cancer Imaging

Table 1

Biodistribution of ^99mTc-N4-AMT in Normal Fischer 344 Rats.

	30 MIN	120 MIN	240 MIN
blood	0.74 ± 0.024	0.28 ± 0.010	0.18 ± 0.008
heart	0.18 ± 0.013	0.08 ± 0.006	0.05 ± 0.003
lung	0.44 ± 0.029	0.22 ± 0.004	0.13 ± 0.008
thyroid	0.57 ± 0.040	0.31 ± 0.015	0.24 ± 0.012
pancreas	0.18 ± 0.006	0.09 ± 0.005	0.06 ± 0.002
liver	1.40 ± 0.077	0.83 ± 0.045	0.60 ± 0.023
spleen	0.24 ± 0.004	0.19 ± 0.002	0.18 ± 0.011
kidney	5.77 ± 0.355	5.32 ± 0.180	4.74 ± 0.332
stomach	0.50 ± 0.029	0.42 ± 0.031	0.43 ± 0.026
intestine	0.33 ± 0.019	0.18 ± 0.010	0.13 ± 0.006
uterus	0.34 ± 0.014	0.14 ± 0.023	0.08 ± 0.004
muscle	0.09 ± 0.007	0.03 ± 0.002	0.02 ± 0.001
bone & joint	0.27 ± 0.061	0.11 ± 0.006	0.06 ± 0.003
brain	0.03 ± 0.005	0.01 ± 0.001	0.01 ± 0.000

Each value is the percentage of injected dose per gram weight (n = 3)/time interval. Each datum represents the mean of three measurements with standard deviation.