Glucose Tolerance and Left Ventricular Pressure-Volume Relationships in Frequently Used Mouse Strains

Table 2

Pressure-conductance analysis in 4 mice background strains. All data are expressed as mean  ±  standard deviation. Values marked with ^ψ are 𝑃<.05 versus ^∆ and values marked with * are 𝑃<.05 versus all others.

Heart rate (bpm)	623  ±  71*	569  ±  43	545  ±  40	566  ±  35
Ves (uL)	10.9  ±  5.1^ψ	16.5  ±  6.2^∆	9.0  ±  3.1^ψ	18.0  ±  4.6^∆
Ved (uL)	30.7  ±  9.1	31.8  ±  7.2^ψ	25.8  ±  7.1^∆	30.0  ±  9.9
Pes (mmHg)	69.5  ±  9.9	76.8  ±  8.2	71.9  ±  8.0	84.2  ±  13.6*
Ped (mmHg)	1.2  ±  1.7	1.9  ±  2.0	1.2  ±  1.2	2.9  ±  2.9
𝑃max (mmHg)	90  ±  5^ψ	84  ±  6^∆	88  ±  7	89  ±  11
EF (%)	70.4  ±  11.2^∆	55.9  ±  13.4^ψ	71.8  ±  9.2^∆	47.8  ±  5.7^ψ
Cardiac output (uL/min)	14038  ±  4530*	10405  ±  2683	10438  ±  3251	8466  ±  3013
d𝑃/d𝑡max (mmHg/s)	11746  ±  2105*	7162  ±  1563	9420  ±  2268	7760  ±  1581
d𝑃/d𝑡min (mmHg/s)	−7738  ±  2098	−7948  ±  1242	−8204  ±  1458	−8547  ±  1464
Tau	4.1  ±  0.7^ψ	5.2  ±  0.9^∆	4.5  ±  0.7^ψ	5.2  ±  0.8^∆
Arterial elastance (Ea) (mmHg/μL)	3.4  ±  1.2	4.4  ±  1.2	4.1  ±  1.1	6.2  ±  1.9*
Ees	9.5  ±  5.0	6.1  ±  2.1	8.4  ±  3.8	8.2  ±  2.9
EDPVR (mmHg/μL)	0.265  ±  0.082	0.218  ±  0.074	0.316  ±  0.079	0.415  ±  0.159*
Preload recruitable stroke work (PRSW) (mmHg)	92  ±  22	88  ±  21	94  ±  25	82  ±  23
Efficiency (SW/PVA)	0.78  ±  0.054	0.70  ±  0.08	0.70  ±  0.13	0.60  ±  0.11*