Research Article

Glucose Tolerance and Left Ventricular Pressure-Volume Relationships in Frequently Used Mouse Strains

Table 3

Pressure-conductance analysis in 4 mice background strains under increasing isoproterenol. All data are expressed as mean  ±  standard deviation. Values marked with * are versus previous value, if versus previous value, and if between 0 and 90 ng/kg/min.

Isoproterenol
(ng/kg/min)
HR
(bpm)
Ves
(uL)
Ved
(uL)
Pes
(mmHg)
Ped
(mmHg)
EF
(%)
CO
(uL/min)
Ees EDPVR
(mmHg/μL)
PRSW
(mmHg)
Efficiency
(SW/PVA)

Swiss 0 623  ±  71 10.9  ±  5.1 30.7  ±  9.1 69.5  ±  9.9 1.2  ±  1.7 70  ±  11 14038  ±  4530 9.5  ±  5.0 0.265  ±  0.082 92  ±  22 0.78  ±  0.05
3681  ±  7710.3  ±  7.030.1  ±  9.765.9  ±  14.9−2.1  ±  2.272  ±  1315832  ±  53748.9  ±  4.20.221  ±  0.065101  ±  180.79  ±  0.04
90720  ±  796.8  ±  5.724.9  ±  7.2*56.1  ±  17.7−5.1  ±  2.1*‡79  ±  1615537  ±  55499.3  ±  6.10.239  ±  .08782  ±  390.76  ±  0.050
C57BL6/J0569  ±  4316.5  ±  6.231.8  ±  7.276.8  ±  8.21.9  ±  2.056  ±  1310405  ±  26836.1  ±  2.10.218  ±  0.07488  ±  210.70  ±  0.08
3586  ±  50*13.6  ±  7.1*31.2  ±  7.664.1  ±  9.60  ±  2.564  ±  1712196  ±  34056.2  ±  1.80.216  ±  0.076102  ±  240.69  ±  0.05
90681  ±  41*‡4.7  ±  5.6*‡24.7  ±  8.445.0  ±  13.8*‡−2.8  ±  2.5*‡88  ±  1416245  ±  481811.0  ±  5.50.256  ±  0.084106  ±  300.77  ±  0.14
DBA20545  ±  409.0  ±  3.125.8  ±  7.171.9  ±  8.01.2  ±  1.272  ±  910438  ±  32518.4  ±  3.80.316  ±  0.07994  ±  250.70  ±  0.13
3615  ±  505.0  ±  3.8*21.4  ±  3.5*87.1  ±  23.4−1.3  ±  1.283  ±  16*11634  ±  324614.7  ±  6.90.266  ±  0.133102  ±  230.75  ±  0.09
90671  ±  393.9  ±  3.015.3  ±  3.5†‡61.5  ±  16.4−4.7  ±  2.0*‡83  ±  159918  ±  3574*15.6  ±  5.80.239  ±  0.04994  ±  270.74  ±  0.07
BalbC0566  ±  3517.5  ±  4.630.0  ±  9.984.20  ±  13.622.9  ±  2.948  ±  68466  ±  30138.2  ±  2.90.415  ±  0.15982  ±  230.60  ±  0.11
3586  ±  26*16.4  ±  4.828.4  ±  9.9*86.2  ±  8.52.8  ±  3.1*49  ±  48464  ±  28048.5  ±  2.60.382  ±  0.11393  ±  19*0.63  ±  0.11
90733  ±  50*‡4.9  ±  4.119.3  ±  4.561.5  ±  19.5−2.0  ±  2.8*‡81  ±  1311760  ±  195811.1  ±  1.70.314  ±  0.105*‡117  ±  6*‡0.70  ±  0.06*‡