Research Article
Animal Models of Colitis-Associated Carcinogenesis
Table 3
Examples of CAC in genetically engineered mice with DSS treatment.
| | Gene | Treatment | Cycles | Invasive carcinoma (%) | References |
| Apc min+/−
Apc min+/− | 4% DSS
2% DSS | 2
1 | 40
100 | Makiyama et al., 2005 [110] Tanaka et al., 2006 [111] |
| iNOS−/−
iNOS+/+ | 1% DSS + high
Iron | 15 | 68
65 | Van Assche et al., 2005 [87] |
| P53−/−
P53+/−
P53+/+ | 4% DSS | 3 + 120 days | 53.9
22.3
0 | Rutgeerts et al., 2006 [83] |
| Msh2−/−
Msh2+/−
Msh2+/+ | 5% DSS | 3–8 | 16.7
8
13.3 | Cooper et al., 2000 [100] |
| Brp39−/−
Brp39+/+ | AOM + 3.5% DSS | 3 | 37.5
87.5 | Segawa et al., 2010 [26] |
|
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Abbreviations: AOM, azoxymethane; APC adenomatous polyposis coli; DSS, dextran sulfate sodium; NOS, nitric oxide synthase; Brp39, breast regression protein 39.
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